大麻の使用と脳の機能への影響

タイトル: Impact of year-long cannabis use for medical symptoms on brain activation during cognitive processes

概要: ImportanceCannabis is increasingly being used to treat medical symptoms, but the effects of cannabis use on brain function in those using cannabis for these symptoms is not known. ObjectiveTo test whether brain activation during working memory, reward, and inhibitory control tasks, areas of cognition impacted by cannabis, showed increases following one year of cannabis use for medical symptoms. DesignThis observational cohort study took place from July 2017 to July 2020 and is reported on in 2024. SettingParticipants were from the greater Boston area. ParticipantsParticipants were recruited as part of a clinical trial based on seeking medical cannabis cards for anxiety, depression, pain, or sleep disorders, and were between 18 and 65 years. Exclusion criteria were daily cannabis use and cannabis use disorder at baseline. Main Outcomes and MeasuresOutcomes were whole brain functional activation during tasks involving working memory, reward and inhibitory control at baseline and after one year of cannabis use. ResultsImaging was collected in participants before and one year after obtaining medical cannabis cards; 57 at baseline (38 female [66.7%]; mean [SD] age, 38.0 [14.6] years) at baseline, and 54 at one-year (37 female [68.5%]; mean [SD] age, 38.7 [14.3] years). Imaging was also collected in 32 healthy control participants (22 female [68.8%]; mean [SD] age, 33.8 [11.8] years) at baseline. In all groups and at both time points, functional imaging revealed canonical activations of the probed cognitive processes. No statistically significant difference in brain activation between the two timepoints (baseline and one-year) in those with medical cannabis cards and no association of changes in cannabis use frequency with brain activation were found. Conclusions and RelevanceFindings suggest that adults do not show significant neural effects in the areas of cognition of working memory, reward, and inhibitory control after one year of cannabis use for medical symptoms. The results warrant further studies that probe effects of cannabis at higher doses, with greater frequency, in younger age groups, and with larger, more diverse cohorts. Trial Registration: NCT03224468, https://clinicaltrials.gov/ Key PointsO_ST_ABSQuestionC_ST_ABSThis study investigated the impact of year-long cannabis use for medical symptoms on brain activation during cognitive processes implicated in cannabis use. FindingsFunctional magnetic resonance imaging during a working memory, reward, and inhibitory control task was collected at baseline and after one year of medical cannabis card ownership. After one year, brain activation did not differ statistically from baseline and was not associated with changes in cannabis use frequency. MeaningThe absence of activation differences suggests that adults using cannabis for medical conditions may not experience significant neural effects in regards to reward, working memory, or inhibitory control.