SARS-CoV-2: Pets and the Pandemic
Study reveals how COVID-19 spreads between humans and pets.
Francisco C. Ferreira, Lisa D. Auckland, Rachel E. Busselman, Edward Davila, Wendy Tang, Ailam Lim, Nathan Sarbo, Hayley D. Yaglom, Heather Centner, Heather Mead, Ying Tao, Juan Castro, Yan Li, Jing Zhang, Haibin Wang, Lakshmi Malapati, Peter Cook, Adam Retchless, Suxiang Tong, Italo B. Zecca, Ria R. Ghai, Casey Barton Behravesh, Rebecca S. B. Fischer, Gabriel L. Hamer, Sarah A. Hamer
― 7 min read
Table of Contents
In the world of viruses, SARS-CoV-2 has been quite the troublemaker. This virus is behind COVID-19, and it has been making headlines since 2019. But guess what? It's not just humans that are catching this virus. Our furry friends, like dogs and cats, have also been getting into the virus action, and scientists want to figure out just how much. This article dives into a study that looks at how SARS-CoV-2 spreads between people and their pets. Spoiler alert: it's not exactly a pet party!
Background
SARS-CoV-2 is classified as a zoonotic virus, meaning it can jump between animals and humans. Early on in the pandemic, researchers noticed that pets, especially cats and dogs, could catch the virus from their human owners. While some pets were diagnosed with COVID-19, there were very few cases where humans caught it back from their pets. It's like a one-way street: humans can pass it to pets, but the return trip is rare.
The appearance of new virus variants added a twist to the story. In November 2021, a fast-spreading version of the virus called Omicron showed up. Researchers were eager to learn how this variant affected our pets. Did Omicron spread to dogs and cats? Were they just sitting around watching Netflix while humans dealt with the chaos? Understanding communication between species was the goal of this study.
The Study
This research took place in Texas during a tumultuous time for COVID-19. While humans were battling the virus, researchers decided to investigate pets living in households where people were experiencing COVID-19 symptoms. The idea was to see whether these pets were catching the virus too.
Participants
The study included 105 human participants and 100 pets from 47 households. Each household had at least one person reporting a COVID-19 diagnosis. The number of people in each household ranged from one to seven, and there were one to twelve pets per house. They had a mix of dog lovers and cat enthusiasts, with some households boasting both. Apart from dogs and cats, the study also involved goats, horses, pigs, and even a gecko. One could say it was a mini zoo!
Sampling Process
Researchers didn’t just ring the doorbell and take a quick look. They went into each house three times over two weeks, collecting samples from both humans and their pets. The samples included nasal swabs from people and nasal and oral swabs from pets. They even checked food and water bowls for any trace of the virus. Nothing was off-limits for this virus-hunting team!
The Findings
After all the sampling and testing, there were a few interesting discoveries. Out of the 47 households, 43 had at least one person test positive for SARS-CoV-2. That's a lot of COVID-19 hovering around! The researchers tested how the virus affected both humans and pets, focusing primarily on dogs due to the small number of infected cats.
Detection of SARS-CoV-2
The results showed that about 63.9% of humans tested positive for the virus during the first round of sampling. This number dropped to about 22.6% in the third round. So, while people were becoming infected, the virus was not showing up as frequently over time.
When it came to dogs, only three out of 55 tested positive for the virus. That's around 5.4%. The dogs that tested positive had swabs taken between 2 to 9 days after their humans were diagnosed. Cats, on the other hand, didn't test positive at all. Talk about a cat winning the "not infected" award!
Antibodies and Immunity
The researchers didn't stop at just testing for active infections; they also looked at whether the pets had developed any antibodies against SARS-CoV-2. Antibodies are like little warriors in the body that help protect from viruses. Turns out, some dogs showed signs of having been exposed to the virus in the past, with 20% testing positive for antibodies capable of neutralizing the virus. Cats had a lower rate of 7.7%. It seems our feline friends are doing a good job of keeping the virus at bay.
What About the Food Bowl?
In one of the more surprising findings, a food bowl from a dog tested positive for the virus. That’s right! The food bowl was infected, while the dog was already known to have caught it. It's unclear whether the bowl got contaminated because of the dog or if a sneaky human left traces of the virus behind.
Genetic Tracking
To further unearth the mystery, researchers took a closer look at the genetic makeup of the virus. They compared samples from infected humans, dogs, and the food bowl. They found that the viruses were closely related, suggesting that the virus was indeed circulating within those households.
Interestingly, the researchers identified different variants of the virus in different households, including Omicron subvariants BA.1.1, BA.2.3.4, and BA.5.1.1. It was a wild mix of viral families, but thankfully, all of them seemed to be hanging out only in humans and their pets, without causing too much trouble.
Implications of the Findings
So, what do all these findings mean? Well, it seems that while pets can catch COVID-19 from humans, they are not major players in spreading the virus back to us. The researchers found that the chances of pets transmitting the virus were pretty low, especially for Omicron variants. It’s like a game of tag, but the pets are simply too polite to pass the virus along!
While many pets lived in homes with infected humans, they weren't gobbling up the virus like it was some tasty treat. Most of the pets tested negative, and even those that had antibodies didn’t seem to be infecting other animals.
Study Limitations
Every research project has its quirks, and this one is no different. The small number of cats tested limited the ability to draw strong conclusions about them specifically. Plus, people might not always accurately report their pet’s behaviors, making it tricky to assess potential transmission routes. It’s like trying to figure out who ate the last cookie when everyone swears they didn’t!
Conclusion
In summary, this study shines a light on the relationship between humans, pets, and COVID-19. While pets can catch SARS-CoV-2, especially from their owners, they don’t seem to be significant in spreading the virus back to humans. It’s a bit of an odd situation, but thankfully, households of furry companions can enjoy each other’s company without too much worry.
With new variants emerging, scientists will continue to keep an eye on our beloved pets. After all, they might just help researchers understand the virus better. So, keep those leashes handy and treat those pets with care because they are worth every tail wag!
Future Directions
As COVID-19 continues to evolve and new variants come to light, the importance of exploring how the virus interacts with pets becomes more crucial. Future research will likely focus on expanding the number of animals tested and looking into different types of pets.
Additionally, we should pay attention to how pets experience various strains of the virus over time. If they start exhibiting symptoms or if infection rates change, we might have to reconsider how we interact with our pets during outbreaks.
The ongoing surveillance has the potential to inform us about the broader impacts of COVID-19 on animal populations. In the meantime, let’s keep our furry friends safe and healthy while enjoying their company. After all, they did not sign up for this virus circus!
Original Source
Title: Household clusters of SARS-CoV-2 Omicron subvariants contemporaneously sequenced from dogs and their owners
Abstract: Monitoring the zoonotic potential of emerging SARS-CoV-2 variants in animals is a critical tool to protect public health. We conducted a longitudinal study in 47 households reporting people with COVID-19 in Texas in January-July 2022, during the first Omicron wave. We evaluated 105 people and 100 of their companion animals by RT-qPCR for SARS-CoV-2 at three sequential sampling events 1-2 weeks apart, starting 0-5 days after the first reported diagnosis of COVID-19 in the house. Of 47 households that reported people with COVID-19, SARS-CoV-2 was detected in 43, with 68% of people testing positive by RT-qPCR; 95.5% of people had antibodies to SARS-CoV-2. Dogs were the only animal species positive by RT-qPCR (5.4%; 3/55). Viral copies were consistently lower in dogs than household members, and no infectious virus was recovered in cell culture. Whole genome sequencing revealed household clusters of Omicron subvariants BA.1.1, BA.2.3.4 and BA.5.1.1 in people, dogs and a food bowl, confirming human-to-dog transmission within households, with no evidence of onward transmission from the infected dogs. Eleven dogs (n = 55) and two cats (n = 26) had neutralizing antibodies against SARS-CoV-2. Infection was not associated with clinical signs in pets; only two animals that tested negative for SARS-CoV-2 were reported to be sick. Nearly one-third (30.2%) of households with active COVID-19 had pets exposed to SARS-CoV-2, similar to our pre-Omicron studies, yet incidence of infection in cats was lower compared to pre-Omicron. These differences suggest that the zoonotic transmission dynamics in households may differ based on variant. Significance statementMonitoring companion animals offer insights into the zoonotic potential of SARS-CoV-2 ahead of its introduction into other animal populations where viral spread may go unchecked. At the peak of the first Omicron wave, we assessed SARS-CoV-2 transmission dynamics in households longitudinally testing people and their pets in Texas. Omicron infections in cats were significantly lower when compared to pre-Omicron variants. Whole genome sequencing revealed three household clusters of human-to-dog transmission, each with a different Omicron subvariant, yet we did not find evidence of onward transmission to other animals or humans from infected dogs. Sustained animal surveillance in at-risk animals and people using the One Health approach are critical given the ongoing potential for viral evolution that can impact public health.
Authors: Francisco C. Ferreira, Lisa D. Auckland, Rachel E. Busselman, Edward Davila, Wendy Tang, Ailam Lim, Nathan Sarbo, Hayley D. Yaglom, Heather Centner, Heather Mead, Ying Tao, Juan Castro, Yan Li, Jing Zhang, Haibin Wang, Lakshmi Malapati, Peter Cook, Adam Retchless, Suxiang Tong, Italo B. Zecca, Ria R. Ghai, Casey Barton Behravesh, Rebecca S. B. Fischer, Gabriel L. Hamer, Sarah A. Hamer
Last Update: 2024-12-05 00:00:00
Language: English
Source URL: https://www.medrxiv.org/content/10.1101/2024.12.02.24318339
Source PDF: https://www.medrxiv.org/content/10.1101/2024.12.02.24318339.full.pdf
Licence: https://creativecommons.org/publicdomain/zero/1.0/
Changes: This summary was created with assistance from AI and may have inaccuracies. For accurate information, please refer to the original source documents linked here.
Thank you to medrxiv for use of its open access interoperability.