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Bacteria in Your Mouth: The Hidden Helpers

Learn how oral bacteria impact your health and wellbeing.

Anil K. Chaturvedi, Emily Vogtmann, Jianxin Shi, Yukiko Yano, Martin J. Blaser, Nicholas A. Bokulich, J. Gregory Caporaso, Maura L. Gillison, Barry I. Graubard, Xing Hua, Autumn G. Hullings, Lisa Kahle, Rob Knight, Shilan Li, Jody McLean, Vaishnavi Purandare, Yunhu Wan, Neal D. Freedman, Christian C. Abnet

― 6 min read


Inside Your Mouth: The Inside Your Mouth: The Bacteria Battle overall health. Discover how oral bacteria affect your
Table of Contents

Have you ever thought about the tiny creatures living in your mouth? No, not the leftovers from last night's pizza—I'm talking about bacteria! The community of bacteria in your mouth, known as the Oral Microbiome, is essential for your overall health. While it might sound a bit creepy, these bacteria play a critical role in digestion, immunity, and even your risk for various diseases.

What is the Oral Microbiome?

The oral microbiome is the collection of bacteria and other microorganisms that reside in your mouth. It's like a bustling city of tiny life forms, working together or causing trouble, depending on their mood. These bacteria help break down food and can influence your metabolism, blood pressure, and how your immune system functions.

However, not all bacteria are good. Some can lead to Gum Disease or other health issues, especially if they start to outnumber the friendly ones. Research has shown that changes in this tiny ecosystem can lead to a range of chronic diseases—like diabetes, heart disease, and even various types of cancer. So, keeping your oral microbiome happy is quite important!

The Need for Reference Studies

To really know how the oral microbiome affects health and disease, scientists need a baseline understanding of what a healthy oral microbiome looks like. Unfortunately, most of the research so far focused on small or selective groups of people, which can make it hard to draw clear conclusions. If you think about it, it’s like trying to guess the weather for the entire country based on just one state.

Thus, there is a big need for studies that look at a more representative sample of the population. Luckily, researchers stepped up to the plate to collect data from a wide range of people and provide a clearer picture of our oral friends.

The Study: Who, What, When, and How?

In a large study, researchers analyzed data collected from adults aged 18 to 69 years across the United States. They gathered this information from the National Health and Nutrition Examination Survey (NHANES), which is a fancy name for a survey that tracks the health and nutrition of Americans. This survey isn't just a bunch of questionnaires; it involves interviews and actual health exams, giving a well-rounded view of the population.

As part of this study, oral rinse samples were taken to analyze the oral microbiome. Participants swished and gargled to collect bacteria, which were then sent to a lab for examination. Yes, swishing and gargling like a champion could lead to important insights!

The Complexity of Bacteria

The oral microbiome is a complex world, with over 1,200 different types of bacteria living in harmony—or chaos. Researchers identified 37 different bacterial groups, known as phyla. Among these, six genera (that's a fancy term for groups of related bacteria) were found in nearly everyone, making them the VIPs of our mouth:

  1. Veillonella
  2. Streptococcus
  3. Prevotella
  4. Rothia
  5. Actinomyces
  6. Gemella

These friendly bacteria make up more than 65% of the total bacteria in the mouth. You could say they are the "popular kids" in the oral microbiome. But don’t worry; there’s room for other bacteria, too!

How Does Age Affect Our Microbiome?

As we get older, the composition of our oral microbiome changes. Interestingly, bacteria levels peak around age 30 and then start to decline. So, enjoy your youthful years of good bacteria while they last!

Older adults might find that their mouth produces fewer types of bacteria, especially if they lose teeth, which can reduce Diversity in their oral ecosystem. The takeaway? Keep those pearly whites healthy, and your mouth may just thrive!

Numbers and Diversity

When scientists studied the diversity of bacteria in people’s mouths, they found varying levels of richness depending on various factors. For example, people with better oral health tended to have a higher number of different bacteria types. In contrast, those with severe gum disease had a lower variety of bacteria.

Another interesting tidbit: people who took antibiotics or certain medications often had fewer different bacteria in their mouths. So, if you’re on a medication, it might change the way your bacteria party.

The Role of Lifestyle Choices

Many lifestyle choices can shape our oral microbiome. For instance, smoking and drinking alcohol can decrease the diversity of bacteria in your mouth. On the flip side, maintaining a healthy diet and good oral hygiene can keep that bacteria city thriving.

The study also noted that individuals with Periodontal Disease (a fancy term for gum disease) had a different set of bacteria compared to healthy individuals. Some bacteria thrive in the diseased environment, while others disappear. That’s like inviting the wrong crowd to the party!

The Importance of Socioeconomic Factors

Interestingly, factors like income, education, and ethnicity can also affect the oral microbiome. People from different backgrounds may have different diets or access to dental care, which can influence the types of bacteria that flourish in their mouths.

Certain bacteria’s prevalence and richness varied between different racial and ethnic groups. This highlights the need for a diverse understanding of how our environments impact our health.

The Influence of Bacteria on Health

The connections between the oral microbiome and various health conditions are becoming clearer. For example, individuals with a higher prevalence of certain bacteria are at greater risk for conditions like diabetes and heart disease. It’s almost as if the mouth acts as a window to our overall health.

Research has also shown that the types of bacteria present can influence how well our immune system works. When harmful bacteria take over, it can lead to inflammation and other systemic issues. So, a balanced oral microbiome may contribute to a balanced body!

The Final Word on Oral Microbiome Research

This study provides valuable insights into the oral microbiome of Americans. It offers a clearer view of what makes up a healthy mouth and how various factors, including age, lifestyle, and socioeconomic status, can influence the bacteria that reside there. By knowing more about these tiny creatures, we can better understand their role in our health and find ways to support a flourishing microbiome.

So next time you're brushing your teeth, remember: it's not just hygiene; you're also nurturing a community of hardworking helpers. And who wouldn't want to keep the tiny residents of their mouth happy? After all, a balanced oral microbiome may be the secret to a healthy life!

Original Source

Title: The mouth of America: the oral microbiome profile of the US population

Abstract: ImportanceThe oral microbiome is increasingly recognized to play key roles in human health and disease; yet, population-representative characterizations are lacking. ObjectiveCharacterize the composition, diversity, and correlates of the oral microbiome among US adults. DesignCross-sectional population-representative survey. SettingThe National Health and Nutrition Examination Survey (NHANES, 2009-2012), a stratified multistage probability sample of the US population. ParticipantsNHANES participants aged 18-69 years (n=8,237, representing 202,314,000 individuals). ExposuresDemographic, socioeconomic, behavioral, anthropometric, metabolic, and clinical characteristics. Main outcomesOral microbiome, characterized through 16S rRNA sequencing. Microbiome metrics were alpha diversity (number of observed Amplicon Sequence Variants [ASV], Faiths Phylogenetic diversity, Shannon-Weiner Index, and Simpson Index); beta diversity (unweighted UniFrac, weighted UniFrac, and Bray-Curtis dissimilarity); and prevalence and relative abundance at taxonomic levels (phylum through genus). Analyses accounted for the NHANES complex sample design. ResultsAmong US adults aged 18-69 years, the oral microbiome encompassed 37 bacterial phyla, 99 classes, 212 orders, 446 families, and 1,219 genera. Five phyla-- Firmicutes, Actinobacteria, Bacteroidetes, Proteobacteria, and Fusobacteria and six genera--Veillonella, Streptococcus, Prevotella7, Rothia, Actinomyces, and Gemella, were present in nearly all US adults (weighted-prevalence >99%). These genera also were the most abundant, accounting for 65.7% of abundance. Observed ASVs showed a quadratic pattern with age (peak at 30 years), was similar by sex, significantly lower among non-Hispanic White individuals, and increased with higher body mass index (BMI) categories, alcohol use, and periodontal disease severity. All covariates together accounted for a modest proportion of oral microbiome variability, as measured by beta diversity (unweighted UniFrac=8.7%, weighted UniFrac=7.2%, and Bray-Curtis=6.3%). By contrast, relative abundance of a few genera explained a high percentage of variability in beta diversity (weighted UniFrac: Aggregatibacter=22.4%, Lactococcus=21.6%, Haemophilus=18.4%). Prevalence and relative abundance of numerous genera were significantly associated (Bonferroni-corrected Wald-p

Authors: Anil K. Chaturvedi, Emily Vogtmann, Jianxin Shi, Yukiko Yano, Martin J. Blaser, Nicholas A. Bokulich, J. Gregory Caporaso, Maura L. Gillison, Barry I. Graubard, Xing Hua, Autumn G. Hullings, Lisa Kahle, Rob Knight, Shilan Li, Jody McLean, Vaishnavi Purandare, Yunhu Wan, Neal D. Freedman, Christian C. Abnet

Last Update: Dec 7, 2024

Language: English

Source URL: https://www.medrxiv.org/content/10.1101/2024.12.03.24318415

Source PDF: https://www.medrxiv.org/content/10.1101/2024.12.03.24318415.full.pdf

Licence: https://creativecommons.org/publicdomain/zero/1.0/

Changes: This summary was created with assistance from AI and may have inaccuracies. For accurate information, please refer to the original source documents linked here.

Thank you to medrxiv for use of its open access interoperability.

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