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Advancements in Handheld OCT for Pediatric Eye Care

New handheld OCT improves eye imaging for children and infants.

Angela S. Li, Ryan Imperio, Du Tran-Viet, Shwetha Mangalesh, S. Grace Prakalapakorn, Lejla Vajzovic, Ramiro Maldonado, Sharon F. Freedman, Xi Chen

― 6 min read


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Optical Coherence Tomography (OCT) is a fancy tool that helps doctors take detailed pictures of the inside of the eye, especially the Retina, which is that light-sensitive layer at the back. This tool can help in monitoring eye diseases in children, making it easier for doctors to see what's going on in their tiny eyes.

How Does it Work?

Picture this: If you want to see something inside a cake without cutting it, you'd want to use a tool that can look through the layers. That’s what OCT does for eyes. It sends light into the eye and catches the light that bounces back to create images that show different layers of the retina. The great thing is, it’s quick and usually doesn’t hurt. Most kids can sit still long enough for the scan, which is a relief for parents!

Handheld OCT: A Game Changer

Now, here’s where things get even cooler. There’s a portable version of OCT known as handheld OCT, which is easier to use for smaller kiddos, especially those who are too young or too wiggly for the bigger machines. With handheld OCT, doctors can take pictures of babies and very young children without needing to make them sit in a special chair or have them lie down. This is super helpful for those tiny patients who can’t cooperate yet.

First Uses of Handheld OCT

Handheld OCT was first used for Infants who had experienced serious injuries, such as shaken baby syndrome. It’s also been useful in the neonatal intensive care unit (NICU) for babies born early who might have eye issues. These scans have given doctors valuable information about problems like Macular Edema, which is a swelling that can happen in the eye, and other tricky stuff happening in the periphery of the retina.

The Only Handheld OCT Device

So far, there’s only one option on the market-think of it as the one ice cream flavor available on a hot summer day. It's called the Bioptigen/Leica Envisu C2300. This device has been around for over ten years, which is like a dinosaur in technology terms. Recently, another handheld device called Heidelberg FLEX got approval, but it’s still not as widely used.

The Limitations

However, these devices are not perfect. They have a limited view, meaning they can’t see the entire retina at once. They also take a bit of time to capture images, which could lead to some movement if the baby isn’t still. It’s like trying to take a picture of a cat that won’t sit still-nearly impossible!

What Are We Studying Now?

This brings us to a new study where researchers tested a brand-new handheld OCT system called Theia T1-W. This device is like the cool new kid on the block and is designed to take wider and clearer pictures of the retina. They wanted to see how well it worked in kids, especially those who needed to be examined while under anesthesia (essentially, a deep sleep).

The Study

In this study, they managed to scan 26 eyes belonging to 14 children, ranging from tiny premature babies to teenagers. Most were imaged while asleep in a hospital, with a few getting their pictures taken at the doctor’s office.

What Did They Find?

The researchers found that they could capture the fovea (that’s the spot in the retina that helps with sharp vision), the optic nerve, and parts of the retina around it in a single shot. They were even able to get good quality images of blood vessels toward the edges, which is like being able to see the whole pizza, not just the slice in front of you.

Comparing Devices

In their comparisons, this new handheld device was getting better edge views than the traditional methods, which sometimes left the edges a bit dark. Using this new tool was like turning on a light in a dim room-suddenly, everything becomes much clearer.

More Insights from the Study

They also had a chance to look at the areas between the vitreous (that jelly-like substance in the eye) and the retina, which isn’t easy to see with regular exams. They could see things like vitreous traction, which is just a fancy way to say the jelly is pulling on the retina in a way that it shouldn’t. This could lead to all sorts of problems, like holes or detachments in the retina.

What About Specific Cases?

For kids with conditions like Coats’ disease, they could see clearly what was happening. They saw things like localized swelling and little nodules in the retina that weren’t visible before. It’s kind of like noticing the hidden layers in a lasagna that you couldn’t see from the top.

The Need for Better Tools

While the technological landscape for eye imaging is growing, there are still challenges. The OCT process can take 1-2 seconds, which may not seem long, but in the world of wiggly babies, it is an eternity. Sometimes the images can get a bit blurry if the child moves.

A Bright Future Ahead

This new handheld OCT system promises to bring better imaging to pediatric patients and might make diagnosing and treating eye diseases easier. If more doctors start using it, they could gain a better understanding of how children’s eyes develop and what conditions can cause them trouble.

What’s Next?

As researchers continue their work, there’s hope that wider and faster imaging systems will keep popping up. This could soon become the go-to method for checking on the eyes of little ones. After all, eye health is crucial, and catching problems early on can make a big difference.

Wrapping it Up

In the end, new tools like the handheld OCT are like having superhero gadgets that help doctors protect and care for kids’ eyes. It may not be a cape, but it sure helps doctors see things clearly so they can provide the best care possible. And who wouldn’t want that for our tiny humans?

Original Source

Title: Imaging Infants and Children with Investigational Handheld Optical Coherence Tomography with Widefield Lens: A Pilot Study

Abstract: Handheld optical coherence tomography (OCT) systems have shown promises to provide detailed evaluation of the pediatric retina. It is less stressful for preterm infants compared to binocular indirect ophthalmoscopy and shows promises for screening for retinopathy of prematurity. There are currently only one commercially available non-contact handheld OCT systems, and no commercially available widefield handheld OCT systems. Here we report and evaluate the first use of the Theia Imaging Investigational handheld OCT system with widefield lens (T1-W, Theia Imaging, Durham, NC) in pediatric subjects. We compare the OCT en face view to handheld widefield or tabletop ultra-widefield fundus photographs and evaluate the ability to visualize the vitreoretinal interface, intraretinal, subretinal and choroidal features on cross-sectional OCT scans.

Authors: Angela S. Li, Ryan Imperio, Du Tran-Viet, Shwetha Mangalesh, S. Grace Prakalapakorn, Lejla Vajzovic, Ramiro Maldonado, Sharon F. Freedman, Xi Chen

Last Update: 2024-11-04 00:00:00

Language: English

Source URL: https://www.medrxiv.org/content/10.1101/2024.10.30.24316132

Source PDF: https://www.medrxiv.org/content/10.1101/2024.10.30.24316132.full.pdf

Licence: https://creativecommons.org/licenses/by/4.0/

Changes: This summary was created with assistance from AI and may have inaccuracies. For accurate information, please refer to the original source documents linked here.

Thank you to medrxiv for use of its open access interoperability.

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