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Non-Alcoholic Fatty Liver Disease and Legumes: A Complicated Relationship

Explore the link between legumes and liver health in this overview.

Fie Langmann, Christopher Fisker Jensen, Vibeke Lie Mortensen, Line Rosendal, Niels Bock, Christina C. Dahm

― 5 min read


Legumes and Liver Health Legumes and Liver Health and gallbladder. Investigating legumes' impact on liver
Table of Contents

Non-alcoholic Fatty Liver Disease, or NAFLD, is a health issue that many people will face worldwide. It happens when fat builds up in the liver without a connection to alcohol use. This is not just a small problem; it's a big deal! It’s expected that about 25% of adults will have this condition by 2026.

Two Types of NAFLD

There are two main forms of NAFLD:

  1. Non-Alcoholic Fatty Liver (NAFL): This is when fat forms in the liver but there’s no damage visible.

  2. Non-alcoholic Steatohepatitis (NASH): Here, fat buildup comes with inflammation, and there might be some liver damage.

Both types can lead to serious liver issues and even liver cancer, especially when linked to metabolic syndrome. Unfortunately, there are no approved medications for this condition, and doctors often suggest lifestyle changes, especially when it comes to diet.

Why Legumes?

You may be wondering, "What do beans have to do with a fatty liver?" Well, legumes, like beans, lentils, and chickpeas, pack a punch when it comes to nutrition. They are loaded with protein, low in bad fats, and full of fiber.

The Benefits of Legumes

Legumes help improve diet quality and health. They play a big role in plant-based diets, which can lower the chances of getting sick from lifestyle-related diseases. Eating more legumes instead of fatty meats can help keep our livers happy.

Research on Legumes and NAFLD

There is a buzz about how eating legumes in various diets, like the Mediterranean or vegetarian diets, may help improve liver health. These diets are usually rich in healthy compounds that are good for the body. Who knew beans could be heroes too?

Effects on Fat in the Liver

Studies suggest that eating legumes might help reduce fat in the liver. They can slow down fat absorption in our bodies, which might help keep the liver from getting too full. This could mean a lower risk of NAFLD.

The Gallbladder Connection

Now, let’s talk about the gallbladder. This little pouch under the liver helps store bile, which digests fat. However, a lot of fat can cause problems, including gallstones. Some researchers wonder if eating more legumes could lead to gallstones. It’s like a see-saw; eating healthily may help the liver but might create issues for the gallbladder.

The Mixed Bag of Findings

The research shows mixed results. Some studies suggest that eating lots of legumes leads to less risk of gallbladder issues, while others find a possible link between high legume intake and gallstone formation. It’s a bit confusing, isn’t it?

The Aim of This Review

This review set out to take a closer look at how legumes impact liver and gallbladder health. The focus was on people without existing liver problems, looking at those aged two and older (sorry kids still breastfeeding!).

What Did We Look For?

Our search aimed to gather all the info about legume consumption and its effects on liver and gallbladder diseases, leaving out research on animals and studies that didn’t focus on humans.

What We Found

Study Results

After digging through the research, we came across 29 articles on how legumes affect liver and gallbladder health. Seventeen looked at NAFLD, and twelve focused on gallbladder diseases.

The Diverse Findings

When it comes to legumes and liver health, some studies found that eating more beans may lower the risk of NAFLD. However, the results are all over the place, with a good mix of positive and no association at all.

Gallbladder Diseases

For gallbladder health, the findings were even more mixed. Some studies showed that legumes might make gallbladder issues worse, while others found no link at all. It’s like trying to hit a moving target!

The Quality of Studies

Now, let’s talk about quality. Many of the studies had different methods, which made comparing them tough. Some studies were solid, while others were not so great.

Different Ways of Checking Health

The studies used many approaches to measure liver and gallbladder health. Some used imaging methods to see what was happening inside, while others relied on reports from participants about their health.

The Importance of Measuring Diet

Measuring what people eat is complicated. Some studies relied on short-term reports of what people ate, which may not capture a full picture. Others used questionnaires to keep track of long-term diet, providing more reliable info.

Overall Takeaways

In summary, legumes could be a friendly ally for liver health, but the exact relationship isn’t clear-cut. They may help some folks, while others could face issues, especially related to gallbladder health.

What’s Next?

More research is needed to really understand how legumes affect liver and gallbladder health. With more robust studies, we can cut through the confusion and determine the best dietary choices for everyone.

A Light Note on Our Bean Friends

In the end, incorporating beans into our diet can be both nutritious and delicious-just remember to take it easy on the gas!

Original Source

Title: Consumption of legumes and risk of hepatobiliary diseases among humans aged 2+ years: a scoping review

Abstract: ObjectivesTo identify and map the literature regarding human consumption of legumes and potential relationships with hepatobiliary diseases. BackgroundConsuming legumes might reduce lipid accumulation in the liver while potentially impeding the functionality of the bile duct and gallbladder. As dietary trends shift toward promoting legume consumption, exploring the positive and negative impacts on hepatobiliary health becomes crucial. MethodsThis scoping review explored the intake of dietary pulses and legumes (excluding broader dietary patterns) and their relation to hepatobiliary diseases like non-alcoholic fatty liver disease, gallstones, and gallbladder removal among individuals above the age of two years. The review included textbooks, expert opinions, and searches in four databases (PubMed, CINAHL Complete, Embase, and Web of Science). Two reviewers extracted data independently from each article. The synthesis of results was presented narratively by hepatobiliary outcomes. Unpublished studies and grey literature sources were sought out. ResultsFrom 19,881 records retrieved, 29 were included - 17 on non-alcoholic fatty liver disease and 12 on gallbladder diseases. Most studies were observational, but a few were narrative reviews. Some studies found a protective association between legume consumption and non-alcoholic liver disease, while others found no association. Overall, there was no clear association between legume consumption and gallbladder diseases. The studies varied in methodological quality, and confidence in the findings was low. ConclusionThe association between legume consumption and non-alcoholic fatty liver disease was inverse or non-significant. The association between legume consumption and gallbladder disease was inconclusive. Further research is needed to draw firmer conclusions. Keywords: Dietary pulses; Gallstone; Hepatobiliary health; Legumes; Non-alcoholic fatty liver disease

Authors: Fie Langmann, Christopher Fisker Jensen, Vibeke Lie Mortensen, Line Rosendal, Niels Bock, Christina C. Dahm

Last Update: 2024-11-15 00:00:00

Language: English

Source URL: https://www.medrxiv.org/content/10.1101/2024.11.15.24317376

Source PDF: https://www.medrxiv.org/content/10.1101/2024.11.15.24317376.full.pdf

Licence: https://creativecommons.org/licenses/by/4.0/

Changes: This summary was created with assistance from AI and may have inaccuracies. For accurate information, please refer to the original source documents linked here.

Thank you to medrxiv for use of its open access interoperability.

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