The Rising Threat of STIs in Sub-Saharan Africa
Curable STIs are on the rise in SSA, highlighting urgent health needs.
Julia Michalow, Lauren Hall, Jane Rowley, Rebecca L. Anderson, Quinton Hayre, R. Matthew Chico, Olanrewaju Edun, Jesse Knight, Salome Kuchukhidze, Evidence Majaya, Domonique M. Reed, Oliver Stevens, Magdalene K Walters, Remco PH Peters, Anne Cori, Prof Marie-Claude Boily, Jeffrey W. Imai-Eaton
― 5 min read
Table of Contents
- The Challenge of Monitoring STIs
- Limited Estimates of Curable STIs
- Previous Studies Focused Mostly on Women
- A New Systematic Review
- What the Review Found
- Prevalence Estimates for STIs
- Regional Variations
- Time Trends in STIs
- Differences Between Genders
- Limitations of the Review
- Conclusion
- Original Source
Sexually transmitted infections (STIs) are a serious public health issue, especially in sub-Saharan Africa (SSA). These infections affect millions and can lead to various health problems if left untreated, such as infertility and increased risk of HIV. The World Health Organization (WHO) has set goals to lower the rates of STIs by 2030. Achieving these goals requires better prevention and treatment programs, particularly in SSA, where STI rates are alarmingly high.
The Challenge of Monitoring STIs
Monitoring STIs can be tricky for many reasons. One major issue is that many individuals with STIs do not show symptoms. This asymptomatic nature makes it hard to know how many people are actually infected. Furthermore, people often wait too long to seek help when they do have symptoms, compounding the issue. Another hurdle is the lack of proper testing facilities in some areas, which means that healthcare providers often resort to treating based on symptoms alone rather than using specific tests. Weak Surveillance systems further complicate the assessment of STI rates.
Limited Estimates of Curable STIs
For curable STIs, such as chlamydia, Gonorrhoea, and trichomoniasis, reliable estimates are scarce in SSA. While WHO publishes Prevalence and incidence data globally every few years, these reports do not usually provide detailed regional breakdowns or track changes over time. In addition, the Global Burden of Disease study aims to estimate these figures but relies heavily on the available data and certain assumptions. As a result, estimates, especially for men, are often based on generalized data that might not be accurate for every region.
Previous Studies Focused Mostly on Women
Many studies that have looked at the prevalence of STIs in SSA have primarily focused on women, particularly pregnant women or those involved in HIV prevention trials. While such studies are valuable, they typically do not represent the general population well, especially regarding men. As a result, understanding how STIs affect different groups over time remains a challenge.
A New Systematic Review
To get a clearer picture of the prevalence of chlamydia, gonorrhoea, and trichomoniasis in SSA, a systematic review of studies conducted between 2000 and 2024 was performed. The goal was to gather data from studies that involved adults representing the general population-excluding those in specific high-risk groups-to see how these infections vary by sex, region, and time.
What the Review Found
A thorough search was conducted in multiple databases for relevant studies. A total of 11,136 records were found, which were filtered down to 214 articles representing 211 unique studies. The majority of these studies came from Eastern Africa, followed by Western and Central Africa, and then Southern Africa. Participants mostly included women, with a significant number coming from antenatal care settings. However, only a small percentage involved both men and women together.
Prevalence Estimates for STIs
In 2020, the review estimated the following prevalence rates for STIs in SSA:
- Chlamydia: 6.6% among females and 4.7% among males
- Gonorrhoea: 2.4% among females and 1.7% among males
- Trichomoniasis: 6.8% among females and 1.7% among males
When looking at trends over the past decade, chlamydia prevalence showed a significant increase of about 34.5%, while gonorrhoea and trichomoniasis prevalence did not show statistically significant changes.
Regional Variations
Chlamydia and gonorrhoea show similar trends across different regions. In female populations, Southern Africa had the highest prevalence for both chlamydia and gonorrhoea, while Western and Central Africa had the lowest. In contrast, trichomoniasis prevalence was more consistent across regions for females but much higher in Eastern Africa for males.
Time Trends in STIs
Regarding changes over time, chlamydia prevalence has notably increased in Eastern and Southern Africa. This increase is concerning, particularly since untreated chlamydia can lead to severe long-term health issues for women. On the other hand, trichomoniasis prevalence has declined in Southern Africa, which is good news, but interpretations should be cautious.
Differences Between Genders
The review also calculated male-to-female prevalence ratios for each STI. The ratios indicated that chlamydia and gonorrhoea were more common in females. However, trichomoniasis showed a much lower prevalence among males compared to females. These findings demonstrate the need for gender-sensitive approaches to STI prevention and treatment in SSA.
Limitations of the Review
While this review provides valuable insights, it also has its limitations. The data available was sparse and often varied, which could affect the reliability of the findings. Most studies focused on specific populations, mainly women seeking antenatal care, which may not accurately reflect STI prevalence in the general population. Additionally, the lack of data on men in many studies hinders a clear understanding of how STIs affect them.
Conclusion
In summary, the systematic review highlights the high prevalence of curable STIs in sub-Saharan Africa, with significant geographical differences. While chlamydia rates are on the rise, trichomoniasis has started to decline in certain areas. The findings stress the need for better surveillance to ensure that both men and women receive appropriate prevention and treatment for STIs.
Given the continuous risk associated with STIs, tackling this issue requires more integrated health services to effectively combat these infections. With a little humor, we could say that while love might be in the air, so are STIs-and it’s high time we get some fresh, clean air around here!
Title: Prevalence of chlamydia, gonorrhoea, and trichomoniasis among male and female general populations in sub-Saharan Africa from 2000-2024: A systematic review and meta-regression analysis
Abstract: BackgroundSub-Saharan Africa (SSA) has the highest sexually transmitted infection (STI) prevalence globally, but information about trends and geographic variation is limited by sparse aetiologic studies, particularly among men. This systematic review assessed chlamydia, gonorrhoea, and trichomoniasis prevalence by sex, sub-region, and year, and estimated male-to-female prevalence ratios for SSA. MethodsWe searched Embase, MEDLINE, Global Health, PubMed, and African Index Medicus for studies measuring STI prevalence among general populations from January 1, 2000, to September 17, 2024. We adjusted observations for diagnostic test performance and used log-binomial mixed-effects meta-regressions to estimate prevalence trends and sex-prevalence ratios. FindingsOf 5202 records identified, we included 211 studies from 28 countries. In 2020, estimated prevalence among 15-49-year-olds in SSA for chlamydia was 6.6% (95%CI: 5.0-8.2%, n=169 observations) among females and 4.7% (3.4-6.1%, n=33) among males, gonorrhoea was 2.4% (1.4-3.3%, n=171) and 1.7% (0.7-2.6%, n=31), and trichomoniasis was 6.8% (3.6-9.9%, n=188) and 1.7% (0.7-2.7%, n=19). Male-to-female ratio estimates were 0.61 (0.53-0.71) for chlamydia, 0.81 (0.61-1.09) for gonorrhoea, and 0.23 (0.18-0.28) for trichomoniasis. From 2010-2020, chlamydia prevalence increased by 34.5% (11.1-62.9%) in SSA, while gonorrhoea and trichomoniasis trends were not statistically significant. Chlamydia and gonorrhoea prevalence were highest in Southern and Eastern Africa, whereas trichomoniasis was similar across sub-regions. InterpretationSSA has a high, geographically varied STI burden, with increasing prevalence of chlamydia. Region-specific sex-prevalence ratios differed from existing global ratios and should be considered in future burden estimates. Enhanced sex-stratified surveillance is crucial to guide national programmes and reduce STI prevalence in SSA. FundingGates Foundation, Imperial College London, NIH, UKRI
Authors: Julia Michalow, Lauren Hall, Jane Rowley, Rebecca L. Anderson, Quinton Hayre, R. Matthew Chico, Olanrewaju Edun, Jesse Knight, Salome Kuchukhidze, Evidence Majaya, Domonique M. Reed, Oliver Stevens, Magdalene K Walters, Remco PH Peters, Anne Cori, Prof Marie-Claude Boily, Jeffrey W. Imai-Eaton
Last Update: Dec 16, 2024
Language: English
Source URL: https://www.medrxiv.org/content/10.1101/2024.12.16.24319070
Source PDF: https://www.medrxiv.org/content/10.1101/2024.12.16.24319070.full.pdf
Licence: https://creativecommons.org/licenses/by/4.0/
Changes: This summary was created with assistance from AI and may have inaccuracies. For accurate information, please refer to the original source documents linked here.
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