What does "β-secretase" mean?

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β-secretase is an enzyme that plays a key role in the breakdown of a protein called amyloid precursor protein (APP) in the brain. This process is important for the production of amyloid-beta, a substance that can build up and form plaques in the brains of people with Alzheimer's disease.

When β-secretase cuts APP, it starts a chain of events that can lead to the accumulation of amyloid-beta. This buildup is linked to memory loss and cognitive decline seen in Alzheimer's disease.

In addition to its role in creating amyloid-beta, β-secretase is influenced by other factors in the body. For example, certain proteins can affect its activity, which in turn can impact how much amyloid-beta gets produced.

Therefore, understanding how β-secretase works and how it is regulated is important for finding potential treatments for Alzheimer's disease. By targeting this enzyme, researchers hope to help reduce the harmful effects of amyloid-beta in the brain.