What does "Invasive Aspergillosis" mean?
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Invasive Aspergillosis is a serious infection caused by a type of fungus called Aspergillus, most commonly Aspergillus fumigatus. This infection mainly affects the lungs and can occur in people with weak immune systems, such as those with cancer or those taking certain medications that suppress immunity.
How It Affects the Body
When Aspergillus fumigatus enters the lungs, it can invade the cells that line the airways. The body's immune response kicks in, and certain cell receptors, like the epidermal growth factor receptor (EGFR), play a role in sensing the fungus. This interaction prompts the lung cells to engulf the fungus and release substances that attract immune cells to the infection site.
Risk Factors
People with weakened immune systems, often due to diseases such as cancer or treatments like corticosteroids, are at a higher risk of developing invasive Aspergillosis. Those treated with drugs that block EGFR may also be more likely to get this infection because the immune response is reduced.
Symptoms
Symptoms of invasive Aspergillosis can include coughing, fever, chest pain, and difficulty breathing. If not treated quickly, it can lead to severe complications and even death.
Treatment
Treating invasive Aspergillosis typically involves antifungal medications. However, the success of treatment often depends on the individual's immune system and how quickly the infection is diagnosed. In some cases, additional therapies may be needed to support the immune response.