What does "HR Proficient" mean?

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HR proficient refers to cancer cells that have normal functioning of a process called homologous recombination. This process is important for repairing DNA damage. When this mechanism works well, it helps the cells maintain their genetic stability.

In cancers like breast and ovarian cancer, understanding if a tumor is HR proficient is crucial for choosing the right treatment. Patients with tumors that are not HR proficient may respond better to certain drugs, like PARP inhibitors, which target weaknesses in DNA repair.

Doctors often check for HR proficiency as part of cancer treatment planning. Knowing if a tumor is HR proficient can help avoid giving patients treatments that may not work for them, ensuring a more effective approach to cancer care.