What does "Endothelial To Hematopoietic Transition" mean?

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Endothelial to hematopoietic transition (EHT) is a process where specific cells in blood vessels, called endothelial cells, change into hematopoietic stem cells (HSCs). These HSCs are important because they are the building blocks for blood cells in the body.

During early development, especially in embryos, EHT helps form these stem cells. The process takes place in locations like the aorta, a major blood vessel. When EHT occurs, it produces different types of blood cell progenitors, which are the early forms of blood cells.

Research has shown that there are different types of cells that emerge from EHT, which leads to a variety of blood cells later on. This diversity is important for proper immune function and overall health.

Understanding EHT helps scientists learn how blood cells develop and can aid in creating therapies for blood-related diseases.