What does "Connexin 43" mean?
Table of Contents
Connexin 43 is a protein that forms channels between cells, allowing them to communicate with each other. These channels are important for many functions in the body, especially in the heart and nervous system.
Role in the Heart
In the heart, connexin 43 helps heart cells (cardiomyocytes) work together by allowing electrical signals to pass through. This signaling is essential for the heart to beat properly. If connexin 43 is not working correctly, it can lead to problems like irregular heartbeats and heart dysfunction.
Connection to Disease
Mutations in the gene that makes connexin 43 can cause conditions like left ventricular non-compaction cardiomyopathy (LVNC). People with this condition may be at risk for heart problems, including arrhythmias (irregular heartbeats). Changes in the location and function of connexin 43 are linked to these heart issues.
Role in Nerve Protection
Connexin 43 also plays a part in protecting nerve cells, especially after damage from treatments like chemotherapy. It helps in transferring mitochondria, which are the energy-producing parts of cells, from one cell to another. This transfer supports the survival of nerve cells and prevents damage that can lead to pain and discomfort.
Summary
Connexin 43 is crucial for communication between cells in both the heart and nervous system. Its proper function is vital for heart health and protecting nerves from damage.