What does "CDK4" mean?
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CDK4, or cyclin-dependent kinase 4, is an important protein in the cell cycle, which is the process that cells go through to grow and divide. CDK4 works together with another protein called cyclin D1 to help control how cells progress from one stage of the cell cycle to the next.
Role in Cancer
When CDK4 is not functioning properly, it can lead to uncontrolled cell growth, a key feature of cancer. In many types of cancer, including breast cancer, CDK4 is often found to be overly active. This can cause cells to multiply in ways that are not normal, contributing to tumor development.
Targeting CDK4 in Treatment
Researchers have developed drugs that specifically target CDK4 to slow down or stop the growth of cancer cells. These drugs help in treating certain types of breast cancer, especially those that are hormone receptor-positive. However, some patients may develop resistance to these treatments, making it necessary to explore additional options to continue managing the disease effectively.
Combination with Other Inhibitors
Combining CDK4 inhibitors with other treatments may enhance their effectiveness. For example, researchers are looking at the potential benefits of also using CDK2 inhibitors to further tackle cancer cells that have become resistant to therapy. This combined approach could lead to better outcomes for patients facing challenges in their treatment journeys.