What does "Base Editing" mean?
Table of Contents
Base editing is a new technology that allows scientists to change small parts of DNA in living cells. This method is useful for studying how genes work and can help in finding new treatments for diseases.
How It Works
Base editing uses a tool called CRISPR, which acts like a pair of molecular scissors. Instead of making big cuts in DNA, base editing makes tiny changes to single building blocks of DNA. This is a safer way to change genes without causing major damage.
Benefits
Base editing can reveal important information about how genes affect health and disease. It allows researchers to study specific mutations, which are changes in DNA that can lead to health issues. This knowledge can guide the development of targeted therapies.
Challenges
While base editing is powerful, it can sometimes lead to unwanted changes in DNA, known as bystander edits. These extra changes can interfere with the intended effects of the treatment, making it harder to restore normal function, especially in diseases like Leber congenital amaurosis, which affects vision.
Future Prospects
Scientists are working on improving base editing to make it more precise and reliable. As they develop better tools, base editing could play a significant role in medicine, helping to treat genetic disorders effectively.