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Assessing HIV Trends in Zambia: Data Challenges

Examining non-response issues and methods to estimate HIV prevalence in Zambia.

― 6 min read


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Sub-Saharan Africa is home to millions of people living with HIV. Accurate data about HIV trends is crucial for governments to create effective policies and support programs. Over the last twenty years, national surveys, especially from the Demographic and Health Survey system, have provided valuable insights into these trends.

However, one significant issue with these surveys is non-response, where some individuals do not participate for various reasons. This non-response can skew data because those who do not respond may have different health outcomes or behaviors compared to those who do. Understanding why people do not respond is complex. Non-response can come from two main sources: non-contacts, where people are not reachable, and refusals, where individuals choose not to participate. Each of these has different underlying reasons, but they are often discussed together for simplicity.

When estimating HIV Prevalence using survey data, researchers worry about potential bias due to non-response. Some studies have examined this issue across different countries, focusing on the rates of participation and evaluating how non-response can affect HIV Estimates. Some have assumed that non-response does not provide any information and have tried to estimate HIV levels among those who did not respond using statistical methods. Others have attempted to use additional data to correct for bias caused by refusals.

To calculate more accurate HIV estimates, researchers have tried several methods. One involves using what are called "instrumental variables." These are factors that can help account for the non-response issue. However, finding valid instruments is challenging, and ensuring they work as intended is not straightforward. This paper discusses these challenges further.

Researchers have found that when there is missing data, it limits what a study can achieve compared to if all data were available. Some scholars argue that missing data cannot be fully replaced with assumptions or models, highlighting the uncertainty it creates. For instance, if researchers don't know whether a particular instrument is valid, they can consider multiple options, even if they don't all provide the right answer.

The study introduces a modified method that aims to reduce uncertainty. By using a group of candidate instruments, it suggests that even if some are incorrect, at least one will be valid, allowing for more reliable bounds to be created for data. This might mean taking a broader view of the data but ensures that the final estimates are closer to the true values.

Simulations have been used to test this new method, with researchers assuming certain conditions and examining how the data behaves under various scenarios. They discovered that using instruments can improve estimates, especially in situations where non-response is high or the bias from refusals is significant.

HIV Testing in Zambia: An Overview

This study focuses on HIV data from the 2007 Zambia Demographic Health Survey, which plays an important role in understanding population health trends. A total of nearly 8,000 households were involved, with a significant number of interviews conducted to gather demographic and health information.

Among eligible individuals for HIV testing, a substantial percentage of both men and women refused to participate. The main reasons for this non-response included not being home during visits or outright refusing the test. It was noted that men were less often available compared to women, which further complicated data collection.

The interviews were conducted by trained teams who spoke a variety of local languages to ensure participants understood the questions. The survey collected a wealth of information beyond just HIV status, including personal habits, economic factors, and attitudes toward health.

The observed HIV prevalence rates among those tested showed variation among different genders and age groups. While the non-response rates were notable, using instruments in analyses helped improve the accuracy of estimates. Researchers considered various factors that might affect non-response, such as the interviewer’s experience or the timing of the interviews, to craft better models for analysis.

Methods for Estimating HIV Prevalence

To estimate HIV prevalence accurately, it's essential to adjust findings based on who did not respond or participate in the tests. Typically, researchers use Imputation, filling in missing data based on characteristics of those who did participate. This creates estimates that reflect a broader range of the population.

However, imputation can sometimes lead to biased estimates, especially if the characteristics of non-tested individuals differ significantly from those tested. To combat this, the study proposes using bounds to estimate HIV prevalence, applying methods that do not rely solely on assumptions.

By examining different candidate instruments related to the survey process, researchers can predict how many individuals are likely to be HIV positive, accounting for those who did not participate. Using these bounds provides a more cautious approach, allowing for a potential range of HIV prevalence instead of a single estimate.

The study also highlights that while imputation leads to narrower confidence intervals, it can cloud the reality of HIV prevalence among non-tested individuals. By acknowledging the uncertainties in the data, researchers can create a more robust understanding of the overall health landscape.

Results from the 2007 Zambia DHS

The 2007 Zambia DHS provided critical data about HIV prevalence among the population. The estimate of HIV positive individuals was based on various demographic factors and achievement of testing. The findings showed differences between men and women and across age groups.

When comparing different methods for estimating HIV prevalence, the results from imputation and partial identification shown notable differences. While imputation resulted in narrower estimates, it also carried the risk of underestimating true prevalence. The proposed method allowed for broader ranges based on assumptions of what the worst-case scenario could be.

This means that while some estimates may point to low prevalence, the partial identification method provides an option for considering higher possible rates based on the uncertainties surrounding non-response.

Conclusion

The study showcases the challenges associated with measuring HIV prevalence, especially in areas with high rates of non-response. By focusing on the role of instruments and providing bounds instead of singular estimates, researchers have a clearer tool for navigating the complexities of the data.

These methods are especially useful for understanding HIV trends in places like Zambia, where non-response is common. The findings underline the need for thoughtful approaches when interpreting health data to ensure accurate reflections of the population's status. With careful analysis, even amidst uncertainties, researchers can provide valuable insights that help shape health policies and interventions.

Original Source

Title: HIV ESTIMATION USING POPULATION-BASED SURVEYS WITH NON-RESPONSE: A PARTIAL IDENTIFICATION APPROACH

Abstract: BackgroundHIV estimation using data from the Demographic and Health Surveys (DHS) is limited by the presence of non-response and test refusals. Conventional adjustments such as imputation require the data to be missing at random. Methods that use instrumental variables allow the possibility that prevalence is different between the respondents and non-respondents, but their performance depends critically on the validity of the instrument. MethodsUsing Manskis partial identification approach, we form instrumental variable bounds for HIV prevalence from a pool of candidate instruments. Our method does not require all candidate instruments to be valid. We use a simulation study to evaluate our method and compare it against its competitors. We illustrate the proposed method using DHS data from Zambia. ResultsOur simulations show that imputation leads to seriously biased results even under mild violations of non-random missingness. Using worst case identification bounds that do not make assumptions about the non-response mechanism is robust but not informative. By taking the union of instrumental variable bounds balances informativeness of the bounds and robustness to inclusion of some invalid instruments. ConclusionsNon-response and refusals are ubiquitous in population based HIV data such as those collected under the DHS. Partial identification bounds provide a robust solution to HIV prevalence estimation without strong assumptions. Union bounds are significantly more informative than the worst case bounds, without sacrificing credibility. Key messagesO_LIPartial identification bounds are useful for HIV estimation when data are subject to non-response bias C_LIO_LIInstrumental variables can narrow the width of the bounds but validity of an instrument variable is an untestable hypothesis C_LIO_LIThis paper proposes pooling candidate instruments and creating union bounds from the pool C_LIO_LIOur approach significantly reduces the width of the worst case bounds without sacrificing robustness C_LI

Authors: Oyelola A Adegboye, T. Fujii, D. H. Leung, L. Siyu

Last Update: 2023-06-05 00:00:00

Language: English

Source URL: https://www.medrxiv.org/content/10.1101/2023.06.03.23290936

Source PDF: https://www.medrxiv.org/content/10.1101/2023.06.03.23290936.full.pdf

Licence: https://creativecommons.org/licenses/by/4.0/

Changes: This summary was created with assistance from AI and may have inaccuracies. For accurate information, please refer to the original source documents linked here.

Thank you to medrxiv for use of its open access interoperability.

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