Simple Science

Cutting edge science explained simply

# Health Sciences# Ophthalmology

Addressing Disparities in Diabetic Eye Care

Research reveals the need for timely screenings to prevent vision loss in diverse groups.

― 6 min read


Diabetic Eye CareDiabetic Eye CareDisparities Exposedpopulations.preventing vision loss across diverseTimely screenings critical for
Table of Contents

Diabetic Retinopathy is a common eye problem that affects people with diabetes and can lead to vision loss. It is a big concern worldwide. Thankfully, if caught early, treatment can help prevent or slow down sight loss.

In the UK, the NHS set up the Diabetic Eye Screening Programme (DESP) in 2003 to identify people with diabetic retinopathy so they can get the care they need. Currently, this program carries out about 2.3 million eye Screenings every year, resulting in around 13 million retinal images taken. Over the years, the number of screenings and images has increased.

How Screening Works

When someone gets their eyes checked through the DESP, trained professionals look at the images to find any signs of diabetic retinopathy. If they find serious issues that could threaten someone's vision, the individual is referred to a hospital for further assessment and potential treatment.

With more and more patients needing these screenings and limited resources in a publicly funded Healthcare system, this process is becoming increasingly challenging for healthcare providers.

Biennial vs. Annual Screening

Studies have shown that checking in every two years, instead of every year, may be safe and save money for those not at high risk. However, some evidence disagrees, stating that there isn't enough proof to recommend screenings beyond one year.

In 2016, the UK National Screening Committee (NSC) suggested moving to biennial screenings for those at low risk of losing their sight. This recommendation was based on a review of almost 350,000 patients across various regions in the UK, which showed that only a small percentage developed serious diabetic retinopathy over a two-year period.

However, some limitations were noted. The data mostly came from past records instead of planned trials, and there were concerns that people might not attend if screenings were spaced out more. Also, the differences among various racial and age groups weren't clearly detailed.

The Impact of Ethnicity

In the UK, certain groups, like South Asian individuals, have a higher risk of diabetes and its complications compared to white people. This makes it important to look at how biennial screenings could affect different Ethnic groups and age ranges.

Despite the recommendation for biennial screenings, many people are still not taking advantage of this option. The concern is that extending the time between screenings might create gaps in healthcare for some groups, particularly those who are already disadvantaged.

The Study

In an effort to address these issues, researchers looked at data from one of the most diverse screening programs in North-East London. They wanted to understand how quickly people without diabetic retinopathy developed serious issues and to see how different groups were affected.

The study involved individuals with diabetes who were screened between January 2012 and December 2021. A set number of people was identified for the study, following ethical guidelines.

The Screening Process

During a screening visit, trained staff take the patient's history and check their vision. They then capture pictures of the back of the eye while the pupil is dilated. Up to three trained graders assess the images for any signs of diabetic retinopathy.

The grading system used classifies retinopathy from no retinopathy to severe cases requiring immediate attention. If the graders cannot assess an image, it is not included in the study.

Data Collection

Researchers collected data from the screening program to understand who was getting screened and to analyze the results. They kept track of important information like age, gender, ethnicity, and type of diabetes to see how these factors affected the risk of developing serious retinopathy.

Findings

From the data involving over 82,000 individuals, the researchers looked at the rates of developing serious diabetic retinopathy. They found that younger people and those from certain ethnic backgrounds were at higher risk than others.

Men generally had lower rates of serious conditions compared to women, and those with Type 1 diabetes had higher risks than those with Type 2. Importantly, the study found that people from black and South Asian backgrounds had much higher risks for serious retinopathy.

The Impact of Biennial Screening

The researchers also explored what might happen if biennial screenings were put in place. They predicted that if this change occurred, a significant number of people would not have their serious conditions detected in time, leading to a delay in treatment.

Amongst those screened, a notable portion who developed serious diabetic retinopathy or proliferative diabetic retinopathy (which is a more severe type) would remain undiagnosed for an entire year if screenings were spaced out. These delays could lead to more severe and potentially irreversible vision loss.

Importance of Timely Detection

The findings highlight that timely detection is crucial, especially for younger individuals who may face longer durations of diabetes if their condition isn't monitored closely. Delayed diagnoses could further widen the gap in health outcomes for certain groups, particularly in a diverse and economically challenged region.

Addressing Healthcare Inequalities

The findings make it clear that simply following the NSC's recommendation for biennial screenings could worsen existing disparities in healthcare. Ethnic and age-related factors should be considered when determining screening intervals to avoid further inequalities in care.

The Role of Technology

Using technology, like artificial intelligence (AI), could help maintain annual screening rates without overwhelming healthcare resources. In some places, AI has already been successfully used to assist in diabetic eye screening. Despite its promise, AI is not yet commonly used in the NHS screening program in England.

AI could potentially reduce the workload of human graders and maintain accuracy in identifying whether patients have diabetic retinopathy. If AI systems could help streamline the process, they may also play a role in ensuring that annual screenings could continue, especially for those at low risk.

Conclusion

The research showed significant disparities in how different groups develop serious diabetic eye conditions. These disparities must be addressed to ensure equitable healthcare for everyone. While changing to biennial screenings may seem cost-effective, it could inadvertently increase the risk of vision loss for some groups.

To prevent these negative outcomes, healthcare providers could look into alternative solutions that would allow for continued care while addressing the needs of all patient demographics. More studies are needed to explore these solutions and to gather further data on how different groups are affected by diabetic retinopathy.

In summary, the findings call for careful consideration of how changes in screening protocols can impact different people, especially those who are already at risk. Ensuring that everyone gets the right care at the right time is crucial in the fight against diabetic retinopathy and its effects on vision.

Original Source

Title: Two-year recall for people with no diabetic retinopathy: a multiethnic population-based retrospective cohort study using real-world data to quantify the effect

Abstract: Background/AimsThe English Diabetic Eye Screening Programme (DESP) offers people living with diabetes (PLD) annual screening. Less frequent screening has been advocated among PLD without diabetic retinopathy (DR), but evidence for each ethnic group is limited. We examined the potential effect of biennial vs annual screening on the detection of sight-threatening diabetic retinopathy (STDR) and proliferative diabetic retinopathy (PDR) among PLD without DR from a large urban-multi-ethnic English DESP. MethodsPLD in North-East London DESP (Jan-2012 to Dec-2021) with no DR on two prior consecutive screening visits with up to eight years of follow-up were examined. Annual STDR and PDR incidence rates, overall, and by ethnicity were quantified. Delays in identification of STDR and PDR events had 2-year screening intervals been used were determined. FindingsAmong 82,782 PLD (37% white, 36% South Asian, and 16% black people), there were 1,788 incident STDR cases over mean 4.3 (SD 2.4) years (STDR rate 0.51, 95%CI 0.47-0.55 per 100-person-years). STDR incidence rates per 100-person-years by ethnicity were 0.55 (95% CI 0.48-0.62) for South Asian, 0.34 (0.29-0.40) for white, and 0.77 (0.65-0.90) for black people. Biennial screening would have delayed diagnosis by 1-year for 56.3% (1,007/1,788) with STDR and 43.6% (45/103) with PDR. Standardised cumulative rates of delayed STDR per-100,000 for each ethnic group were 1904 (95%CI 1683-2154) for black, 1276 (1153-1412), and 844 (745-955) for white people. InterpretationBiennial screening would have delayed detection of some STDR and PDR by one-year especially among those of black ethnic origin, leading to healthcare inequalities. Key messagesO_ST_ABSWhat is already known on this topic?C_ST_ABSThe UK National Screening Committee currently recommends annual eye screening for diabetic retinopathy among people living with diabetes at high risk of sight loss, but biennial screening among those at low risk of sight loss. Ethnic differences in diabetes and the development of sight-threatening diabetes complications have been reported. The effect of biennial vs annual diabetic eye screening among different ethnic groups at low risk of complications has not been quantified in large multi-ethnic diabetic eye screening programmes in the UK. What this study adds?We provide incidence rates for the development of new sight-threatening diabetic retinopathy and proliferative diabetic retinopathy in a low-risk group, overall and by different ethnic and age groups, in this diverse sociodemographic population without previous diabetic retinopathy. Implementation of biennial screening in this population would have delayed referral to hospital eye services by a year in near half of those with sight-threatening diabetes (56%) and proliferative retinopathy (44%), but higher absolute rates of delay were observed among the youngest and oldest compared with middle aged and pre-retirement age groups, and those of black ethnic origin compared with other ethnic groups. Higher hazards of STDR were observed in younger people. While the absolute number delayed is small relative to the size of the overall cohort, age and ethnic inequalities in delayed identification of complications were apparent. How this study might affect research, practice or policy?National implementation of a 2-year diabetic eye screening interval for people with low-risk diabetic retinopathy grades does not affect all population sub-groups equally with respect to delays in the detection and referral of the most serious eye disease. Younger people and people of black and Asian ethnicities are affected more than other groups with potential effects on vision and treatment outcomes.

Authors: Christopher G Owen, A. Olvera-Barrios, A. R. Rudnicka, J. Anderson, L. Bolter, R. Chambers, A. Warwick, R. Welikala, J. Fajtl, S. Barman, P. Remagnino, Y. Wu, A. Lee, E. Chew, F. Ferris, A. D. Hingorani, R. Sofat, C. Egan, A. Tufail

Last Update: 2023-06-20 00:00:00

Language: English

Source URL: https://www.medrxiv.org/content/10.1101/2023.06.14.23291369

Source PDF: https://www.medrxiv.org/content/10.1101/2023.06.14.23291369.full.pdf

Licence: https://creativecommons.org/licenses/by/4.0/

Changes: This summary was created with assistance from AI and may have inaccuracies. For accurate information, please refer to the original source documents linked here.

Thank you to medrxiv for use of its open access interoperability.

More from authors

Similar Articles