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Rising Obesity Among Hispanic Children: Key Insights

Study highlights the connection between biomarkers and obesity in Hispanic youth.

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Obesity among young people in the United States is a growing problem. The number of children and teens aged 2 to 19 with obesity increased from 17.7% in 2011-2012 to 21.5% in 2017-2020. This issue is especially serious for Hispanic groups and those with low economic status. Children who are obese are more likely to remain obese as adults. This can lead to health problems like diabetes, heart disease, sleep apnea, and certain cancers as they grow older.

One of the health issues related to obesity is a condition called atherosclerosis, which affects the blood vessels and can lead to heart disease. It is known that the risk for developing this condition can start in childhood. By tracking certain biological markers, we can see how obesity can lead to problems later in life.

Body mass index, or BMI, is often used to measure obesity. Studies show that as BMI increases, levels of a protein called Adiponectin decrease. Adiponectin is linked to weight control and energy use. Higher levels of this protein are thought to help the body use sugar and fat more effectively, while lower levels can lead to issues with Insulin, the hormone that controls blood sugar. When insulin levels are too high for too long, this can lead to health complications.

Other markers like C-reactive Protein (CRP), interleukin 6 (IL-6), resistin, and tumor necrosis factor-alpha (TNF-α) can also be affected by obesity. These markers are connected to inflammation and are often found at higher levels in people with obesity. Research has shown that these markers are generally lower when adiponectin levels are high.

In this study, we looked at the link between these biomarkers and the risk of being overweight or obese in Hispanic children in Northeast Tennessee. The study included 114 children aged between 2 and 10 years who were recruited for a health project. After excluding some children for various reasons, we ended up with 107 participants. Data about height, weight, and blood samples were collected, and we used this information to determine the children's weight status.

To understand the impact of different factors, we gathered information about the child's age, sex, and the mother's education level and marital status. We needed to analyze how these factors played a role in obesity.

In our analysis, we found that nearly half of the children were categorized as overweight or obese. The average age of the children was around 6.5 years. Most of the mothers had less than a high school education, while many were married.

When looking closely at the biological markers, we found that adiponectin levels were significantly lower in children who were overweight or obese. On the other hand, insulin levels were higher in this group. Other markers did not show significant differences between the two groups.

Using different statistical methods, we could see that both adiponectin and insulin levels were closely linked to the chances of being overweight or obese. For every unit increase in adiponectin, the risk of being overweight or obese dropped by 4%. Conversely, for every unit increase in insulin, the risk increased by 7%. The factors of age, sex, and the mother’s education and marital status, along with other markers, did not show significant links to weight status.

Our findings suggest that adiponectin and insulin could be important indicators of whether a child might be overweight or obese. Low levels of adiponectin are often linked to insulin resistance, which can increase the risk of metabolic syndrome, a cluster of conditions that increase the chances of heart disease and diabetes.

Interestingly, while BMI is commonly used to identify obesity and has been linked to metabolic syndrome, it's becoming clear that focusing only on weight isn’t enough. It may be more beneficial to also look at metabolic health, which refers to how well the body manages blood sugar and fat. There are cases where individuals may have a high BMI but still be metabolically healthy, indicating that weight loss isn't the only goal for improving health outcomes.

The lack of significant differences in other markers like CRP, IL-6, and TNF-α might indicate that the children in our study hadn’t been overweight long enough for these markers to show noticeable changes. In adults, the relationship between these markers and obesity is more clear, but it seems that in children, adiponectin levels could be a better early predictor of potential health issues related to obesity.

Another point of interest in our study was the role of maternal education. We found a negative link between a mother’s education level and the children’s BMI, though the results weren’t significant. Some studies have shown that children whose parents have a higher education tend to have lower rates of obesity. This could be linked to better access to information about nutrition and healthier lifestyles.

While our study had some limitations, such as a small sample size, we still found meaningful relationships that deserve further exploration. Our research was cross-sectional, meaning we could identify links but not establish cause and effect. More studies are necessary, especially with larger groups, to examine these connections over time.

In conclusion, the study shows that adiponectin appears to be a similar marker in Hispanic children as it is in adults, meaning it could be useful in monitoring health among young Hispanic populations. The markers CRP, IL-6, and TNF-α may not be as relevant for predicting obesity in Hispanic youth at an early stage. Further research in children, particularly in Hispanic communities, is essential to better understand these relationships and help guide future health interventions.

Original Source

Title: INFLAMMATORY MARKERS AND BODY MASS INDEX AMOUNG HISPANIC CHILDREN

Abstract: Background and ObjectivesBody mass index (BMI) is inversely proportional with adiponectin levels among adults, while insulin, C-reactive protein (CRP), interleukin 6 (IL-6), resistin, and tumor necrosis factor-alpha (TNF-) have been linked with elevated BMI. The role and relation of these biomarkers with BMI among Hispanic pediatric populations are less known. Thus, the objective of this cross-sectional study was to examine the association of inflammatory markers with the odds of overweight/obesity while controlling for several sociodemographic factors among a Hispanic youth population of Northeast Tennessee. MethodsHeight, weight, demographic information, and blood samples were collected from 107 Hispanic children aged 2 to 10 years recruited at a large community health center in 2015-2016 in Northeast Tennessee. Data for this research were accessed and analyzed in 2022. Multivariable logistic regression was conducted to assess the relations between adiponectin, insulin, resistin, CRP, TNF-, and IL-6, and overweight/obesity vs. having a healthy (normal) weight. ResultsAdiponectin levels were significantly lower among overweight/obese Hispanic children (p = 0.0048) compared to healthy weight children. The odds of overweight/obesity decreased by 4% for every one-unit increase in serum adiponectin. Insulin levels were significantly higher among overweight/obese Hispanic children (p = 0.0048) compared to healthy weight children (p=0.0008). The odds of overweight/obesity increased by 7% for every one-unit increase in serum insulin. Resistin, IL-6, TNF-, and CRP were not significantly associated with overweight/obesity in this population. ConclusionAdiponectin behaves similarly in Hispanic youth as it does in other pediatric populations, possibly making it a valuable marker when examining metabolic health status in this population.

Authors: Arsham Alamian, H. Lang, E. N. Loudermilk, W. A. Clark, J.-A. Marrs, T. A. Joyner, L. Wang, K. S. Gerber

Last Update: 2023-07-24 00:00:00

Language: English

Source URL: https://www.medrxiv.org/content/10.1101/2023.07.21.23293009

Source PDF: https://www.medrxiv.org/content/10.1101/2023.07.21.23293009.full.pdf

Licence: https://creativecommons.org/publicdomain/zero/1.0/

Changes: This summary was created with assistance from AI and may have inaccuracies. For accurate information, please refer to the original source documents linked here.

Thank you to medrxiv for use of its open access interoperability.

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