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Boosting Cervical Cancer Screening Participation

A study shows self-sampling kits can increase cervical cancer screening rates.

― 6 min read


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Table of Contents

Cervical Cancer is a serious health issue that can be prevented. One way to prevent it is through vaccination against human papillomavirus (HPV), a virus linked to cervical cancer. Despite the advancements in prevention, cervical cancer remains a common diagnosis and a leading cause of death for women worldwide. In 2020, it was estimated that over 600,000 new cases were diagnosed, resulting in around 340,000 deaths. The problem is particularly severe in countries with fewer resources, but it also affects certain groups of women in wealthier nations.

To tackle this issue, the World Health Organization has begun a global effort to eliminate cervical cancer. One key part of this initiative is regular screening for cervical cancer, which helps identify women at risk so they can receive early treatment. However, to be effective, screening needs to reach as many women as possible, especially those who do not regularly go for check-ups. Since HPV infection is the main cause of cervical cancer, sending out Self-sampling kits for HPV testing could be a smart way to reach those who are usually overlooked in screening programs.

Importance of Screening

Cervical cancer screening is crucial for reducing the number of cases and deaths. Regular Screenings enable healthcare providers to catch potential issues early. The traditional method involves a visit to the doctor, which can be a barrier for many women. To make the process easier, self-sampling kits allow women to collect samples at home and send them to a lab for testing. Numerous studies have shown that self-sampling is not only accepted but also effective.

Since 1960, the Czech Republic has been conducting pap smear tests during routine health check-ups. In 2008, the country organized a nationwide screening program, encouraging women to have regular Pap tests. As part of this program, women aged 35 and 45 are now also recommended for HPV tests alongside Pap tests.

To further boost Participation, the Czech Republic has introduced personalized invitations for women who have not been attending screenings. This approach is aimed at increasing awareness and encouraging individuals to take part in regular health checks.

The Study

In a recent study, researchers aimed to see if sending HPV self-sampling kits directly to older women could increase participation in cervical cancer screenings. The study was conducted in collaboration with a health insurance company and took place over two months in early 2021.

Eligible women aged 50 to 65, who had not participated in screenings for the last three years, were selected. These women were then randomly divided into two groups. One group received HPV self-sampling kits by mail, while the other received standard invitation letters encouraging them to visit a doctor.

The women in the self-sampling group received easy-to-follow instructions on how to collect their samples, along with information about HPV and cervical cancer. After sending back their samples to a lab, they would receive their results and advice on the next steps if necessary.

Results of the Study

The study found that overall participation was significantly higher among those who received the self-sampling kits compared to those who got the standard letters. Out of the women who received the kits, 13.4% participated, whereas only 5.0% of those who received regular letters did. This indicates that directly mailing the kits was an effective way to encourage women to take part in screenings.

In the self-sampling group, 59 women submitted their samples for testing, and another 48 attended a screening exam with their doctor. In contrast, the control group had a much lower overall response rate. The difference in participation between the two groups was significant.

Among those who returned the self-sampling kits, about 22% tested positive for hrHPV, with a notable number of women carrying high-risk types of the virus. Most of the women with positive results followed up with their healthcare providers for further examinations.

Why Self-Sampling Works

The findings from this study support the idea that self-sampling kits can successfully engage women who may not usually participate in health screenings. This method can remove barriers such as the need for in-person visits and reduce discomfort associated with clinical exams. Women often find it easier to collect samples at home, which may lead to higher participation rates.

Research has shown that many women appreciate the option of self-sampling, as it gives them more control over the process. It also allows them to avoid the anxiety that can come with a visit to a healthcare professional. By adapting the way screenings are offered, health systems can reach more women, particularly those who have never been tested or who have not attended screenings in a long time.

Additional Considerations

While this study focused on a specific group of women, the results could have implications for broader cervical cancer screening programs. The positive response to direct mailing of self-sampling kits indicates that this approach could be beneficial in various healthcare settings.

It's important to note that, although the study was well-structured, the groups were not formally randomized, which could lead to some differences in the results. However, careful selection of participants aimed to ensure that both groups were similar in key factors.

Another factor that may have affected participation was the necessity for women to provide consent for participation and personal data processing. This requirement could deter some individuals. A potentially smoother process, such as moving to paperless systems, could help improve participation even further.

Wider Application

While the study was conducted with one health insurance company in the Czech Republic, its findings are likely relevant to the entire country’s healthcare system. Since all health insurance companies follow a similar personalized invitation process, direct mailing of self-sampling kits is a feasible method for enhancing participation rates across the board.

Although direct mailing is effective, it is essential to keep in mind that a significant number of women still did not respond, even with this approach. Therefore, healthcare providers could look at adding different methods for distributing self-sampling kits, such as offering them through hospitals, clinics, or community health programs to reach those who might be interested.

Conclusion

The study clearly illustrates that sending HPV self-sampling kits directly to women can lead to significantly higher participation rates in cervical cancer screenings. This method provides a practical way to reach those who may otherwise not engage in regular health checks. By removing barriers associated with traditional screening processes, healthcare systems can improve women's health outcomes and potentially reduce the incidence of cervical cancer.

Encouraging more women to participate in screenings is crucial for early detection and successful treatment of cervical cancer. The positive results from this study underline the importance of adapting health programs to meet the needs of specific populations. Through innovative strategies and tools, we can foster better participation in screenings, ultimately leading to improved health for women everywhere.

Original Source

Title: Direct mailing of HPV self-sampling kits to older women non-participating in cervical screening in the Czech Republic

Abstract: BackgroundA population-based cervical cancer screening programme is implemented in the Czech Republic. However, participation is insufficient among women over 50 years. This study aimed to estimate the potential improvement in participation through directly mailed HPV self-sampling kits (HPVssk) compared to standard invitation letters in women aged 50-65 non-participating in screening. MethodsThe study recruited 1,564 eligible women (no cervical cancer screening in the last 3 years or more, no previous treatment associated with cervical lesions or cervical cancer). Eight hundred women were mailed with an HPVssk (HPVssk group), and 764 women were sent a standard invitation letter (control group) inviting them to a routine screening (Pap test). The primary outcome was a comparison of the overall participation rate between study groups using a binominal regression model. ResultsThe participation rate in the HPVssk group was 13.4% (95% CI 11.2-15.9%; 7.4% of women returned the HPVssk and 6.0% attended gynaecological examination) and 5.0% (95% CI 3.6-6.8%) in the control group. Using the binominal regression model, the difference between the groups was estimated as 7.6% (95% CI 5.0-10.2%; p < 0.001). In the HPVssk group, 22% of women who returned HPVssk had a positive result and 70% of them underwent a follow-up examination. ConclusionsCompared to traditional invitation letters, the direct mailing of the HPVssk achieved a significantly higher participation rate, along with a notable HPV positivity rate among HPVssk responders. This approach offers a potentially viable method for engaging women who have not yet attended a cervical screening programme.

Authors: Ondrej Majek, O. Ngo, R. Chloupkova, D. Cibula, J. Slama, L. Mandelova, K. Hejduk, M. Hajduch, P. Minka, V. Koudelakova, H. Jaworek, M. Trnkova, P. Vanek, V. Dvorak, L. Dusek

Last Update: 2023-10-05 00:00:00

Language: English

Source URL: https://www.medrxiv.org/content/10.1101/2023.10.05.23296387

Source PDF: https://www.medrxiv.org/content/10.1101/2023.10.05.23296387.full.pdf

Licence: https://creativecommons.org/licenses/by/4.0/

Changes: This summary was created with assistance from AI and may have inaccuracies. For accurate information, please refer to the original source documents linked here.

Thank you to medrxiv for use of its open access interoperability.

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