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Your Skin's Hidden Helpers: The Role of Corynebacteria

Uncovering the crucial role of Corynebacteria in our skin health.

Reyme Herman, Sean Meaden, Michelle Rudden, Robert Cornmell, Anthony J. Wilkinson, Barry Murphy, Gavin H. Thomas

― 6 min read


Corynebacteria: The Corynebacteria: The Unsung Skin Heroes health and body odor. Exploring how bacteria shape our skin
Table of Contents

The human Skin is home to a wide variety of tiny creatures, specifically Microbes, that help keep our skin healthy. Think of them as little helpers that live on our skin. This community of microbes is known as the skin microbiome, and it includes friendly bacteria, fungi, and other microorganisms. They all work together to maintain the skin's health and protect us from harmful invaders.

Interestingly, the skin isn’t uniform; it has different areas that can be dry, moist, or oily. These differences affect the types of microbes that thrive in each area. For example, the oily parts of the skin, like the face, can support different microbes compared to the dry parts, like the elbows.

Meet the Corynebacteria

One of the major groups of microbes found on our skin is called Corynebacteria. These are a type of bacteria that enjoy living in the various nooks and crannies of our bodies. Some common types include C. jeikeium, C. amycolatum, and C. kroppenstedtii. While they are mostly harmless, some can become troublemakers under certain conditions.

In our underarms, for instance, these bacteria can produce substances that contribute to body odor. You might think stinky underarms are all about sweat, but it’s really the bacteria breaking down skin oils and sweat. This interaction creates the not-so-pleasant odors we all know.

What Are We Learning About These Bacteria?

Recent research has taken a closer look at the underarm bacteria, especially Corynebacteria, to learn more about their roles and behaviors. Scientists collected swabs from volunteers to see what types of bacteria live there. In their findings, they discovered more than 200 different strains of Corynebacteria, some of which were completely new to science!

By studying these tiny creatures, researchers hope to understand how they work together to protect our skin. Some of these bacteria can even help prevent harmful bacteria, such as Staphylococcus aureus, from causing infections. It’s like having bodyguards made of bacteria!

The Science of Scent

Ever wondered why some people have stronger body odors than others? It turns out that the types of bacteria living in our underarms can influence this. For instance, a certain type of Corynebacteria has been linked to higher levels of odor. Scientists are piecing together the connection between these microbes and the distinct smells they create.

In one study, researchers found that nearly 60% of bacteria in the underarms belonged to the Corynebacterium group. Knowing this helps us understand why our armpits can smell different depending on the microbial mix living there.

Digging Deeper into Genomes

For a clearer picture of what’s going on, scientists looked at the genetic material of these bacteria. They found that many strains had unique characteristics and abilities. By examining their genomes, or the complete set of their genetic information, researchers identified differences that might explain how these bacteria function.

Interestingly, while we generally know a lot about other skin bacteria, Corynebacteria didn’t have as much genetic information available. A big reason for this is that many studies in the past focused on other types of bacteria.

The Role of Technology

With advances in technology, researchers are now able to gather genetic information more easily and affordably. They used a method called long-read whole genome sequencing, which helps them get a complete picture of these bacteria without missing any details.

This new technique means researchers can analyze a large number of bacteria from a single spot, like the underarm, without needing to go through a lengthy filtering process first. This allows them to discover new species and understand the full range of genetic diversity present in the microbes.

The Findings: A Collection of Unique Bacteria

After analyzing samples from four volunteers, researchers found seven different species of Corynebacteria, two of which appeared to be completely new. While some species were well-known, others had not previously been linked to healthy skin. This highlights how much more there is to learn about the microbes living on us.

For example, one of the new species, which they playfully named C. axilliensis, seemed to be quite common among the samples, accounting for a significant portion of the bacteria found. It’s as if this little guy was throwing a party in the armpits!

A Closer Look at Bacterial Differences

As researchers examined the genetic makeup of these bacteria, they noticed distinct differences between the species. Some bacteria had special abilities, such as producing small molecules that can protect against harmful microorganisms. Others seemed to be equipped with various systems to fight off potential threats.

Understanding these differences helps researchers paint a more detailed picture of how skin bacteria protect us. For instance, some bacteria can produce antimicrobials that fight off other germs, which keeps our skin healthier.

The Mystery of Body Odor

The bacteria living in our underarms don’t just help protect us; they also contribute to body odor. Some species of Corynebacteria are particularly good at transforming sweat into odorous compounds. This can feel a little unfair, as some of us can blame our body odor on our bacterial buddies!

But there’s more to the story. Researchers found that specific strains of Corynebacteria can actually help reduce the growth of odor-causing bacteria. If only everyone knew who they had to thank for their fresh scent!

Navigating Bacterial Defenses

Aside from producing helpful compounds, these bacteria have tricks up their sleeves to defend against threats. They possess systems to prevent viruses, known as phages, from invading. These defenses help maintain a healthy balance in the skin ecosystem, ensuring the friendly bacteria can thrive while keeping out potential troublemakers.

Using advanced bioinformatics tools, researchers identified the various defense mechanisms present in Corynebacteria. This information could eventually lead to new strategies for maintaining healthy skin or even developing better skin care products.

Conclusion: The Bigger Picture

The human skin microbiome is a complex and dynamic environment, filled with a variety of microbes that work together to keep us healthy. Although we’ve established that Corynebacteria are an important part of this mix, they have often been overlooked in favor of other skin bacteria.

New research shines a light on their roles, revealing surprising contributions to skin health and body odor. With advanced technology making it easier to study these tiny organisms, the future looks bright for further discoveries.

As we continue to learn about the bacteria on our skin, we might find new ways to manage body odor, bolster defenses against infections, and understand more about our overall health. So, the next time you think about skin care, remember to say thank you to your friendly neighborhood bacteria. They’re doing more for you than you might realize!

A Humorous Side Note

And let’s not forget, while we might be scrubbing with the fanciest soaps and perfumes, sometimes the real superstar is the humble Bacterium helping to keep our skin in check. Who knew your armpits could host a scientific conference of their own?

Original Source

Title: Revealing the diversity of commensal corynebacteria from a single human skin site

Abstract: BackgroundOur understanding of the skin microbiome has dramatically improved since the pioneering studies and the improvements in sequencing technologies. Species of the genus Corynebacterium are known to form a major part of the human skin microbiome but most detailed studies have focussed on other similarly prevalent genera like Staphylococcus and Cutibacteria. Prior to this study, there were few complete genomes for skin commensals of the genus Corynebacterium, with only 9 complete genomes available for the most commonly identified species C. tuberculostearicum. ResultsIn this study we explored the genus Corynebacterium from a single body site by swabbing the axilla/underarm of 4 individuals and using a selective media to enrich for corynebacteria. We then generated whole genome sequencing data of these corynebacteria enriched isolates using long-read sequencing and subsequent bioinformatics analysis to reveal an unparalleled diversity of this genus from a single skin site. Through this approach, we obtained the closed genomes of 215 isolates, 154 derived from a single individual. With this genetic information, we were able to identify 7 different species including species previously not associated to the skin and two novel species provisionally named C. axilliensis and C. jamesii. We used pangenome analysis on 30 genetically distinct isolates spanning the 7 species to identify putative metabolic differences, antimicrobial resistance profiles, novel biosynthetic gene clusters (BGCs), prophages and phage defence systems. ConclusionsOur culture-based Nanopore sequencing approach has dramatically improved our overall knowledge of skin corynebacteria, and uniquely here also providing in-depth analysis from a single skin site, revealing a multitude of differences between the isolates. Here we not only improved our knowledge of axillary corynebacteria but also greatly expanded the publicly available number of cutaneous corynebacterial genomes complementing recent studies seeking to understand the diversity of skin corynebacteria.

Authors: Reyme Herman, Sean Meaden, Michelle Rudden, Robert Cornmell, Anthony J. Wilkinson, Barry Murphy, Gavin H. Thomas

Last Update: 2024-11-30 00:00:00

Language: English

Source URL: https://www.biorxiv.org/content/10.1101/2024.11.28.625817

Source PDF: https://www.biorxiv.org/content/10.1101/2024.11.28.625817.full.pdf

Licence: https://creativecommons.org/licenses/by/4.0/

Changes: This summary was created with assistance from AI and may have inaccuracies. For accurate information, please refer to the original source documents linked here.

Thank you to biorxiv for use of its open access interoperability.

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