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AI in the Fight Against Childhood Pneumonia

AI holds promise for improving pneumonia diagnosis in young children in Nigeria.

Taofeeq Oluwatosin Togunwa, Abdulhammed Opeyemi Babatunde, Oluwatosin Ebunoluwa Fatade, Richard Olatunji, Godwin Ogbole, Adegoke Falade

― 5 min read


Fighting Pneumonia with Fighting Pneumonia with AI pneumonia in children. AI offers new hope for diagnosing
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Pneumonia is a serious illness that affects many young children around the world. In fact, it is one of the top reasons why children under five die. In 2015 alone, around 700,000 children in this age group lost their lives to pneumonia, with most cases occurring in lower-income countries. Sub-Saharan Africa, particularly Nigeria, is facing a huge problem with pneumonia among young kids. In 2021, Nigeria had the highest number of pneumonia deaths in children under five, with around 169,000 cases. This shows that urgent and effective solutions are needed to tackle this preventable disease.

Causes and Diagnosis of Childhood Pneumonia

Pneumonia in young children is mostly caused by viruses, with respiratory syncytial virus (RSV) being a major player. However, bacteria also cause severe pneumonia, especially in kids who already have health issues. Diagnosing pneumonia in places like sub-Saharan Africa often relies on doctors’ judgments rather than advanced testing. Some signs, such as trouble eating, convulsions, and low body temperature, indicate severe cases.

While most kids recover from pneumonia, about 3-5% can face serious problems, which can lead to long-term health issues or even death. In Nigeria, the cost of treating childhood pneumonia can be significant, and many families can struggle to afford it. Some reports suggest that nearly 40% of households in Uganda face financial troubles because of the costs associated with treating childhood pneumonia.

To diagnose childhood pneumonia, doctors usually conduct clinical assessments and may use laboratory tests. If outpatient treatment fails or if kids are admitted to the hospital, doctors turn to imaging techniques like chest X-rays. Unfortunately, interpreting these images can vary widely among radiologists, leading to inconsistencies in diagnosis. Adding to the challenge, Nigeria is severely short on healthcare resources, with only a handful of radiologists available to serve a large population.

The Role of Technology in Diagnosis

In recent years, technology has made impressive strides in the medical field, especially regarding diagnosing illnesses. Artificial intelligence (AI), in particular, is increasingly being used to help identify diseases from medical images. One common method employed is called convolutional neural networks (CNNs), which are good at recognizing patterns in images. They have shown promise in detecting various health conditions, including pneumonia.

Some efforts have already been made to develop AI systems that can identify pediatric pneumonia using CNN models. These models have outperformed individual models, achieving impressive accuracy rates. However, many of these AI tools have not yet been put to the test in clinical settings, especially in Africa, where such models are desperately needed. Hence, there is a drive to create AI tools specifically designed to help diagnose pneumonia in Nigerian children.

Developing an AI Model

The aim of ongoing research is to develop an AI model that uses CNNs to detect pneumonia in children under five. This model would utilize chest X-rays from children in Ibadan, Nigeria. The training data consists of thousands of chest X-rays categorized as either normal or showing pneumonia.

The research team gathered a large set of images for training, validating, and testing the AI model. The model's performance was evaluated based on its accuracy in identifying whether a chest X-ray indicated pneumonia or not. Training involved numerous steps to adjust the model's parameters to improve its ability to classify the images correctly.

Outcomes and Observations

During training, the AI model showed signs of improvement across several important metrics. It was initially trained with a base model and then fine-tuned to enhance its ability to recognize pneumonia in children. After extensive training, the model reached a point where it could successfully identify pneumonia in many cases. However, its performance varied when tested on external datasets, particularly when it came to identifying pneumonia accurately.

The results demonstrated some weaknesses in the model's ability to generalize across different contexts. It performed well on the internal test data but struggled when faced with external data, highlighting the need to adapt AI technologies to local conditions.

One humorous takeaway here is the realization that while technology can be rather impressive, it may still need a bit of “local flavor” to truly shine. Just like a good recipe, sometimes you need the right ingredients—the same can be said for AI models and their training datasets!

Implications for Healthcare

The findings of this research point to the essential role AI can play in diagnosing childhood pneumonia in regions with limited healthcare resources. However, there is a strong emphasis on the need for developing localized AI models that can adapt to the specific needs of communities, particularly in low-resource settings like Nigeria.

Policymakers and healthcare providers need to prioritize building strong imaging databases to support the development of reliable AI tools. These databases, filled with high-quality images from local cases, could lead to more accurate diagnostic resources that can truly help in the fight against pneumonia.

Challenges and Future Directions

Despite the potential of AI in healthcare, several challenges remain. For instance, the differences in image quality and acquisition between high-income countries and low-income ones may hinder the model's performance. Moreover, while the AI model was based on a single architecture, exploring a range of models could potentially enhance accuracy.

Moving forward, researchers should investigate the specific differences between local datasets and those used for training AI models. By understanding these disparities, they can better tailor AI systems to meet local healthcare needs.

Conclusion

The battle against pneumonia in young children is ongoing, particularly in areas like Nigeria, where the illness poses a significant threat. While AI technology presents a valuable tool for improving diagnosis, it must be adapted to local contexts to be successful. The findings from this research serve as a stepping stone toward developing AI solutions that are not just clever but also effective in real-world, low-resource settings. By working together to build a comprehensive approach to healthcare, we can help protect the most vulnerable members of our communities. After all, a healthier future begins with the children of today!

Original Source

Title: Detection of Pneumonia in Children through Chest Radiographs using Artificial Intelligence in a Low-Resource Setting: A Pilot Study

Abstract: BackgroundPneumonia is a leading cause of death among children under 5 years in low- and-middle-income-countries (LMICs), causing an estimated 700,000 deaths annually. This burden is compounded by limited diagnostic imaging expertise. Artificial intelligence (AI) has potential to improve pneumonia diagnosis from chest radiographs (CXRs) through enhanced accuracy and faster diagnostic time. However, most AI models lack validation on prospective clinical data from LMICs, limiting their real-world applicability. This study aims to develop and validate an AI model for childhood pneumonia detection using Nigerian CXR data. MethodsIn a multi-center cross-sectional study in Ibadan, Nigeria, CXRs were prospectively collected from University College Hospital (a tertiary hospital) and Rainbow-Scans (a private diagnostic center) radiology departments via cluster sampling (November 2023-August 2024). An AI model was developed on open-source paediatric CXR dataset from the USA, to classify the local prospective CXRs as either normal or pneumonia. Two blinded radiologists provided consensus classification as the reference standard. The models accuracy, precision, recall, F1-score, and area-under-the-curve (AUC) were evaluated. ResultsThe AI model was developed on 5,232 open-source paediatric CXRs, divided into training (1,349 normal, 3,883 pneumonia) and internal test (234 normal, 390 pneumonia) sets, and externally tested on 190 radiologist-labeled Nigerian CXRs (93 normal, 97 pneumonia). The model achieved 86% accuracy, 0.83 precision, 0.98 recall, 0.79 F1-score, and 0.93 AUC on the internal test, and 58% accuracy, 0.62 precision, 0.48 recall, 0.68 F1-score, and 0.65 AUC on the external test. ConclusionThis study illustrates AIs potential for childhood pneumonia diagnosis but reveals challenges when applied across diverse healthcare environments, as revealed by discrepancies between internal and external evaluations. This performance gap likely stems from differences in imaging protocols/equipment between LMICs and high-income settings. Hence, public health priority should be developing robust, locally relevant datasets in Africa to facilitate sustainable and independent AI development within African healthcare. Author SummaryPneumonia is a leading cause of death in children under five, especially in low-resource settings like Nigeria, where access to diagnostic tools and expertise is limited. Our study explores how artificial intelligence (AI) can help address this gap by detecting pneumonia from chest X-rays. We trained an AI model using a large dataset of childrens X-rays from the United States and tested it on images collected in Nigeria. While the AI model performed well on the U.S. data, its accuracy dropped significantly when tested on the Nigerian X-rays. This reveals how differences in imaging techniques and equipment between countries can affect the performance of such models. It highlights the need for AI systems to be adapted to local contexts to ensure they are reliable and effective in real-world settings. Our findings underline the importance of creating high-quality, locally relevant datasets in Africa to support the development of AI tools that address the unique challenges of the region. By investing in such efforts, we can improve access to life-saving technologies, particularly for vulnerable populations in resource-limited healthcare systems.

Authors: Taofeeq Oluwatosin Togunwa, Abdulhammed Opeyemi Babatunde, Oluwatosin Ebunoluwa Fatade, Richard Olatunji, Godwin Ogbole, Adegoke Falade

Last Update: 2024-12-02 00:00:00

Language: English

Source URL: https://www.medrxiv.org/content/10.1101/2024.12.01.24318269

Source PDF: https://www.medrxiv.org/content/10.1101/2024.12.01.24318269.full.pdf

Licence: https://creativecommons.org/licenses/by/4.0/

Changes: This summary was created with assistance from AI and may have inaccuracies. For accurate information, please refer to the original source documents linked here.

Thank you to medrxiv for use of its open access interoperability.

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