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Fighting Malaria: The Importance of Reporting Side Effects

Ghana's Seasonal Malaria Chemoprevention relies on reporting side effects for success.

Abdul Gafaru Mohammed, Dora Dadzie, George Adu Asumah, Isaac Adomako, Joel Jeffrey Idun-Acquah, Paul Boateng, Nana Yaw Peprah, Keziah L. Malm

― 6 min read


Malaria Misreporting: A Malaria Misreporting: A Hidden Crisis threatens children’s health in Ghana. Failure to report side effects
Table of Contents

Malaria is a serious disease caused by parasites that are transmitted through the bites of infected mosquitoes. Children under 5 years old are the hardest hit by this disease, especially in regions where malaria is common. To fight this problem, Ghana has turned to a method called Seasonal Malaria Chemoprevention (SMC). This method gives kids treatments during the rainy season when malaria is more likely to strike.

What is Seasonal Malaria Chemoprevention?

Seasonal Malaria Chemoprevention (SMC) is a proactive approach where children receive malaria drugs at certain times during the year. This method aims to stop children from getting sick with malaria by keeping enough medicine in their bodies to fight off the disease. It is like giving kids a shield before the mosquitoes come out to play.

Ghana adopted SMC in 2013. The process started on a small scale in a district called Lawra and later expanded to cover many other areas. By 2021, SMC programs reached 72 districts in Northern and Eastern regions, along with a few others, helping many children avoid malaria.

The Role of Medicines in SMC

The success of SMC relies on a combination of drugs known as amodiaquine and sulfadoxine-pyrimethamine. These medicines work together to keep malaria at bay. However, any medicine can have side effects, and these are called Adverse Drug Reactions (ADRs). It’s essential to keep an eye on these reactions, as they can affect how families feel about the medications.

In Ghana, Caregivers—often the parents—are asked to report any side effects their children might experience after taking the malaria medicine. Unfortunately, not everyone feels comfortable doing so, and the rates of reporting these side effects are less than ideal.

The Importance of Reporting Adverse Drug Reactions

So why is it crucial to report these adverse drug reactions? When caregivers report side effects, it can help health officials understand how the medicine is working and if any changes need to be made. However, in Ghana, many people do not report ADRs, leading to a lack of information that could improve treatments.

In Ghana, a passive reporting system relies largely on parents and caregivers to report any adverse reactions. This system means that if caregivers don’t report, health officials may not be aware of the side effects occurring in children, which can then impact trust in the SMC program.

What Are the Common Side Effects?

Some of the common side effects reported by caregivers include:

  • Diarrhea
  • Vomiting
  • Fever
  • Abdominal pain

These side effects can happen quickly after taking the medicine—sometimes within hours. Caregivers sometimes manage these reactions at home, thinking they don’t need professional help. This is often not the best approach, as waiting for things to improve on their own can lead to more significant issues.

The Challenges of Reporting

Reports indicate that only a small number of caregivers actually communicate any side effects to health facilities. For example, in a recent study, less than 17% of caregivers who noticed adverse reactions reported them. This rate of reporting is quite low when compared to other regions, like South Africa, where many more people communicated similar experiences.

The reasons for low reporting can vary. Some caregivers might not know what an adverse drug reaction is, or they may not understand their importance. Others may feel that reaching out for help is not worth the trouble. If a caregiver thinks, “My child’s fever will go away on its own,” they might decide not to report it. The same goes for parents who are unsure about how to contact health professionals or may be too busy to seek help.

Factors Influencing Reporting Rates

Several factors can impact whether caregivers report adverse drug reactions:

  1. Knowledge: If caregivers know what ADRs are and understand why reporting them is essential, they are more likely to communicate any issues.

  2. Communication: Having easy access to healthcare personnel or information on how to report issues can encourage caregivers to share their experiences.

  3. Marital Status: Interestingly, unmarried caregivers tend to report ADRs more frequently than their married counterparts. This could be because married caregivers often have to consult their partners before making health decisions, which can slow down the reporting process.

  4. Health Access: If a caregiver knows they can reach a healthcare provider easily—like through a hotline or by visiting a facility—they are more likely to report.

  5. Age and Education: Younger caregivers often report less compared to older ones, and those who have received training about ADRs are more likely to report any adverse events.

Educating Caregivers

Education plays a vital role in improving reporting rates. Caregivers need to be informed about potential side effects of the treatment their children are receiving. When caregivers are educated about what to expect, they will more likely recognize when something unusual happens and take action.

Moreover, health workers should focus on providing caregivers with clear information about how to manage mild side effects. For instance, if a child develops a fever or mild diarrhea, caregivers should know what to do and when to seek further help.

The Role of Community Health Workers

Community health workers are essential in bridging the gap between healthcare systems and families. They can educate caregivers, remind them about the importance of reporting, and help them feel more comfortable doing so.

These workers can visit homes, talk about the medicines being given, and explain what adverse reactions might occur. By building trust with families, they can help ensure that caregivers feel supported when reporting adverse reactions.

The Way Forward

To improve the reporting of adverse drug reactions in Ghana, health officials are encouraged to implement strategies such as:

  1. Regular Education Sessions: Host community meetings to educate families about malaria and the importance of SMC, as well as how to report any issues.

  2. Simple Reporting Mechanisms: Establish easy ways for caregivers to report adverse reactions, like hotlines or online forms.

  3. Follow-up Visits: Health workers should make follow-up visits, especially after administering SMC, to check on children and remind caregivers to report any issues.

  4. Build Trust: Work on building trust between health personnel and communities, as this can significantly improve communication and reporting rates.

Conclusion

Seasonal Malaria Chemoprevention is a promising method to protect children from the dangers of malaria in Ghana. However, for it to succeed, caregivers must actively report any adverse drug reactions. By understanding the common side effects, recognizing the factors influencing reporting, and providing essential education and support, it is possible to improve the situation.

As we continue to tackle malaria, let’s remember that every report counts! It can help ensure that children get the best protection possible against this widespread disease. And, who knows, it could even save someone’s favorite snack from being thrown up unexpectedly!

Original Source

Title: Caregivers Decision to Report Adverse Drug Reactions among Children Receiving Seasonal Malaria Chemoprevention in Ghana

Abstract: IntroductionThe antimalarial medicines used in Seasonal Malaria Chemoprevention (SMC) campaigns are generally well-tolerated but adverse drug reactions (ADRs) can occur. Monitoring, reporting, and prompt management of ADRs is essential to build and maintain trust in SMC campaigns in the implementing communities. The caregivers decision to report ADRs represents a critical issue at the intersection of public health, child welfare, and pharmacovigilance. As SMC campaigns continue to expand, it is imperative to understand and address the factors influencing caregivers decisions to report ADRs. MethodsA mixed methods cross-sectional study involving questionnaire administration, focus group discussions, and review of childrens health records was employed to collect data from caregivers of children aged 3-59 months in the Northern, North-East, and Savanna regions of Ghana. A systematic random sample of 679 caregivers was recruited for the study across three regions. Data including ADR occurrence, maternal and child characteristics was collected from selected caregivers in their homes. Logistic regression was performed for associations between caregivers reports of ADRs and caregiver characteristics. ResultsAbout 49.5% (336/679) of caregivers mentioned the occurrence of ADRs in children after receiving SMC medication. The commonly cited ADR was diarrhea (34.7%, 116/336). Only 16.9% (57/336) of caregivers reported ADRs to the health workers at the time of occurrence. After adjusting for confounders, increasing age of child (aOR=1.04, 95%CI:1.008-1.065), receiving education on ADR reporting (aOR=4.03, 95%CI:4.366-6.119), education on management of mild ADRs (aOR=4.43, 95%CI:2.094-9.808) and having a means of reaching health personnel (aOR=1.56, 95%CI:1.202-2.037) increased the odds of ADR reporting while increasing age of caregivers (aOR=0.92, 95%CI:0.883-0.966) and being married (aOR=0.17, 95%CI:0.149-0.183) decreased the odds of reporting ADRs among the caregivers studied. ConclusionLess than 20% of caregivers whose children experienced ADRs after receiving SMC medication reported the incident. Caregiver education on ADRs and its management and means of reaching the health team were modifiable factors that influenced caregiver ADR reporting.

Authors: Abdul Gafaru Mohammed, Dora Dadzie, George Adu Asumah, Isaac Adomako, Joel Jeffrey Idun-Acquah, Paul Boateng, Nana Yaw Peprah, Keziah L. Malm

Last Update: 2024-12-05 00:00:00

Language: English

Source URL: https://www.medrxiv.org/content/10.1101/2024.11.28.24318172

Source PDF: https://www.medrxiv.org/content/10.1101/2024.11.28.24318172.full.pdf

Licence: https://creativecommons.org/licenses/by/4.0/

Changes: This summary was created with assistance from AI and may have inaccuracies. For accurate information, please refer to the original source documents linked here.

Thank you to medrxiv for use of its open access interoperability.

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