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Combating Hepatitis B: A Community Approach

New strategies aim to raise awareness and improve treatment for hepatitis B in South Africa.

Gloria Sukali, Jacob Busang, Jaco Dreyer, Thandeka Khoza, Marion Delphin, Nonhlanhla Okesola, Carina Herbst, Elizabeth Waddilove, Janine Upton, Janet Seeley, Collins Iwuji, Motswedi Anderson, Philippa C Matthews, Maryam Shahmanesh

― 6 min read


Hepatitis B: Community Hepatitis B: Community Solutions Needed and combined treatment strategies. Tackling hepatitis B through awareness
Table of Contents

Hepatitis B is a virus that can seriously harm the liver and is a major health issue worldwide. There's a goal to wipe it out as a public health threat by 2030, but reaching this goal is like trying to catch a greased pig—it's slippery and challenging. The World Health Organization (WHO) has laid out some ambitious targets to help manage this situation, especially in places with high infection rates.

The Role of Medication

To help people at risk, certain medications called nucleos(t)ide analogues (NAs) are given to reduce the risks associated with chronic liver disease. The star of the show here is Tenofovir disoproxil fumarate (TDF), which is on the WHO's essential medicines list and is meant to be cheap and easy to get. However, in many places, especially in Africa, TDF is like that one friend who always cancels plans—it's either not available or too expensive. This makes it hard for many people to get the treatment they need.

New Guidelines for 2024

In March 2024, the WHO rolled out new guidelines that aim to simplify the process of getting treatment for hepatitis B. One of the exciting updates is that if TDF isn’t available alone, it can be paired with another drug. This combination therapy, known as TDF/XTC, is often more affordable in many areas because these drugs are also used for HIV treatment. This means that not only can people get treated for hepatitis B, but they also have a chance to prevent HIV. It’s like hitting two birds with one stone—if the stone isn’t too heavy, that is.

A Co-Endemic Situation

In South Africa, both HIV and hepatitis B are common, making the fight against these diseases even harder. While HIV has seen a lot of attention, leading to widespread education and treatment options, hepatitis B has been like the red-headed stepchild—overlooked and neglected. There’s little awareness about it, and many people simply don't know how to prevent or treat it.

A New Study Approach

To tackle these issues, researchers at the Africa Health Research Institute (AHRI) in KwaZulu-Natal partnered with other institutions to launch a study. They aimed to understand how many young people are infected with hepatitis B while also getting care for sexual health and HIV prevention. This was a smart move—after all, if you’re already talking about sexual health, why not throw in some information about hepatitis B?

Community Engagement

The researchers developed a program called "Thetha nami ngithethe nawe," which means "Talk to me and I'll talk to you" in IsiZulu. This program encourages peer navigators to engage with young people about their health needs. These navigators assess whether young people are at risk for sexually transmitted infections (STIs) and direct them to appropriate care. By revitalizing community health services, the program not only raises awareness but also provides tangible resources for young people.

Screening and Data Collection

As part of this initiative, clinics were set up to provide HIV counseling, testing, and treatment. People who tested negative for HIV were also screened for hepatitis B. This two-for-one approach is great for health systems because it gets more people screened for multiple conditions at once, all without breaking the bank.

Findings from the Study

Between May 2021 and September 2024, thousands of young people engaged with the program. Out of nearly 16,000 young people who were assessed, only a small fraction tested positive for hepatitis B. This low rate suggests that while the hepatitis B vaccination programs may have been effective, there are still gaps in coverage, particularly among young people who might have missed out on early vaccination.

Among those testing positive, many were previously unaware of their hepatitis B status. This is a wake-up call, indicating there is still more work to be done. The majority of those found to be infected were older, possibly owing to the fact that younger generations may have benefited more from vaccination efforts.

PrEP as a Handy Tool

An exciting aspect of this study is the use of Pre-Exposure Prophylaxis (PrEP), which is usually thought of in the context of HIV prevention. In this case, it becomes a dual-purpose tool, benefiting those who are also dealing with hepatitis B. Many of the young people diagnosed with hepatitis B were offered PrEP, and a significant number decided to take it up.

However, a few of them opted out, which raises questions. What could have kept them from trying PrEP? Was it the fear of pills, stigma, or the myths surrounding side effects? While we can only guess, it's clear that addressing these concerns is vital for treatment uptake.

Continuity in Care

While many young people accepted the dual treatment, long-term follow-up showed that not everyone continued to engage with the program. Out of those who took PrEP, only about half returned for refills as instructed. This drop-off is like a bad habit—hard to break, but possible. Keeping patients engaged is crucial for effective treatment.

Future Directions

Looking ahead, there’s a need to find out more about community attitudes towards hepatitis B screening and treatment. Understanding how people in these Communities feel about hepatitis B can help tailor future health programs to better meet their needs.

Moreover, as treatment for HIV evolves, it’s essential to evaluate how these changes affect hepatitis B care. As new methods are tested, we must ensure that they are accessible for everyone, especially for those co-infected with HIV and hepatitis B.

The Big Picture

In the grand scheme of things, addressing hepatitis B is about weaving it into the larger context of sexual and reproductive health. The lessons learned from the fight against HIV can help inform strategies for tackling hepatitis B. The overall goal is to create a system that provides comprehensive care, combining education and treatment in a way that is easy to navigate for the community.

Conclusion

In the end, the fight against hepatitis B, particularly in South Africa, is a complex but essential battle. By integrating these services and raising awareness, there's hope that fewer people will face the hidden dangers of hepatitis B. If health care providers can tackle both HIV and hepatitis B hand-in-hand, it will be a victory worth celebrating. And if the fight against these viruses can be done with a little humor and community spirit, then perhaps it won’t seem like such a daunting task after all!

Original Source

Title: HIV PrEP programmes as a framework for diagnosing and treating HBV infection in adolescents and young adults in KwaZulu-Natal, South Africa

Abstract: BackgroundHepatitis B virus (HBV) is a neglected public health threat with poor community awareness and access to prevention, despite having a safe and effective vaccine. There are still gaps in diagnosis and treatment, particularly in the World Health Organization (WHO) African region. New WHO HBV guidelines, for the first time, include the use of dual therapy for HBV treatment (Tenofovir (TDF) and Emtricitabine or Lamivudine (XTC) due to challenges in accessing TDF monotherapy. TDF/XTC is also recommended as Pre-Exposure Prophylaxis (PrEP) in adolescents and adults at risk of Human Immunodeficiency Virus (HIV).HBV Screening, treatment and prevention need to be decentralized to improve access. We hypothesize that HBV programmes in African settings can use pre-existing HIV infrastructure, in particular building on PrEP programmes, for access to TDF. MethodsAt the Africa Health Research Institute (AHRI) in KwaZulu Natal, South Africa, the new Evaluation of Vukuzazi LiVEr disease - Hepatitis B ( EVOLVE-HBV, UCL ethics ref. 23221/001) research programme explored the PrEP uptake and retention cascade amongst adolescents and youth aged 15-30 year-olds living with HBV through decentralized sexual health /HIV services of the Thetha nami ngithethe nawe and the Long-acting HIV Pre-Exposure Prophylaxis (LAPIS) study (UKZN BREC ethics ref. 473/2019 and 3735/2021). Following point of care testing (POCT) for HBsAg, follow-up venous samples were taken for laboratory confirmation. ResultsOver the time reviewed (May 2021 - Sept 2024), 15,847 adolescents and young adults received a needs assessment by peer navigators in the community, of whom 3481 (21.9%) were eligible for HIV prevention interventions and referred for clinical review. 3431 (98.6%) accepted HBV POCT as part of routine screening, of whom 21 (0.6%) tested positive for HBsAg. These 21 individuals had not previously been aware of their HBV status, but one was already on antiretroviral (ART) for HIV infection. Amongst the remaining 20, 16 were considered eligible for PrEP, 1/16 (6.3%) decided not to take it and 15 (93.8%) started PrEP as a combined intervention for HBV treatment and HIV prophylaxis. When investigating follow up and retention in care, out of the 14/15 (93.3%) that were due for a refill, 8/14 (57,1%) returned for at least 1 refill, amongst whom 6/12 (50%) had two or more refills (Suppl figure 1). O_FIG O_LINKSMALLFIG WIDTH=200 HEIGHT=87 SRC="FIGDIR/small/24318178v1_figS1.gif" ALT="Figure 1"> View larger version (13K): [email protected]@1cd4f51org.highwire.dtl.DTLVardef@127ad9org.highwire.dtl.DTLVardef@13f49ee_HPS_FORMAT_FIGEXP M_FIG O_FLOATNOSupplementary figure 1:C_FLOATNO Care cascade summary of screening, linkage to care, receipt of PrEP and continuation of PrEP for young adults and adolescents accessing sexual and reproductive health services in a rural population in KwaZulu Natal, South Africa. N: number of people represented in each category of the care cascade; HBsAg: Hepatitis B surface antigen; PrEP: Pre Exposure Prophylaxis (in this case used for HIV prophylaxis and HBV treatment). C_FIG ConclusionSexual health and PrEP programmes provide an important opportunity for HBV testing and treatment for young adults across high HIV burden settings. However, attrition from the care cascade at each step highlights the pressing need for interventions that address barriers to sustainable delivery of long-term care. Our HBV and PrEP programmes continue working to support education, clinical evaluation and service development for HBV in these populations.

Authors: Gloria Sukali, Jacob Busang, Jaco Dreyer, Thandeka Khoza, Marion Delphin, Nonhlanhla Okesola, Carina Herbst, Elizabeth Waddilove, Janine Upton, Janet Seeley, Collins Iwuji, Motswedi Anderson, Philippa C Matthews, Maryam Shahmanesh

Last Update: 2024-12-05 00:00:00

Language: English

Source URL: https://www.medrxiv.org/content/10.1101/2024.11.29.24318178

Source PDF: https://www.medrxiv.org/content/10.1101/2024.11.29.24318178.full.pdf

Licence: https://creativecommons.org/licenses/by/4.0/

Changes: This summary was created with assistance from AI and may have inaccuracies. For accurate information, please refer to the original source documents linked here.

Thank you to medrxiv for use of its open access interoperability.

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