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Chikungunya Virus Surge in Brazil: What You Need to Know

Brazil faces a rise in chikungunya cases, prompting urgent public health actions.

Cecília Artico Banho, Maisa Carla Pereira Parra, Olivia Borghi Nascimento, Gabriel Pires Magnani, Maria Vitoria Moraes Ferreira, Ana Paula Lemos, Beatriz de Carvalho Marques, Marini Lino Brancini, Livia Sacchetto, Andreia Francesli Negri, Regiane Maria Tironi Menezes, Juliana Telles de Deus, Cassia Fernanda Estofolete, Nikos Vasilakis, Maurício Lacerda Nogueira

― 6 min read


Chikungunya Outbreak: Chikungunya Outbreak: Urgent Response Needed cases; swift action is crucial. Brazil battles rising chikungunya
Table of Contents

Chikungunya virus (CHIKV) is a pesky little virus that makes people feel miserable with a fever, joint pain, and all sorts of unpleasant symptoms. It is mainly spread by the bite of certain Mosquitoes, particularly the Aedes aegypti and Aedes albopictus species, which are common in warm and humid climates. In Brazil, CHIKV has become a significant Public Health concern, especially in regions where these mosquitoes thrive.

A Brief History of Chikungunya Virus in Brazil

The first sign of CHIKV in the Americas was spotted in 2013, and it didn't take long before it made itself at home in Brazil. By 2014, cases started popping up in various states, particularly in the Northeast and Southeast regions. Since then, the virus has been on a rampage, causing a staggering number of confirmed cases over the years. Between 2017 and 2024, Brazil tallied nearly one million cases, with a good chunk of those being reported in early 2024.

The Current Situation in Brazil

In 2024, alarm bells started ringing as the Southeastern states reported a huge spike in CHIKV cases. São Paulo, in particular, was the hot spot, accounting for a whopping 74.7% of all cases. So, what’s behind this sudden surge? Let’s take a look at some key factors.

Mosquito Population Explosion

More mosquitoes mean more chances for the virus to spread. The Aedes mosquitoes are not just hanging around; they are thriving in São Paulo, especially in cities with poor sanitation. This provides the perfect breeding ground for these little bloodsuckers. With rising temperatures, the conditions are just right for these mosquitoes to breed and multiply.

Climate Change is Real

As temperatures rise, so do the chances of mosquito reproduction. Change in climate leads to longer breeding seasons. In drier and cooler seasons, mosquitoes can stick around longer than they used to, which means more time to bite and spread the virus.

A Vulnerable Population

The people living in these regions are particularly vulnerable since many have low immunity to CHIKV. Studies have shown that there isn’t much existing immunity within the population, which leaves many folks open to infection. This creates a perfect storm for CHIKV to spread unchecked.

Co-circulating Viruses

To add to the chaos, CHIKV isn't the only troublemaker in town. It’s currently mixing in with other viruses like dengue, which can cause similar symptoms. This overlapping of diseases complicates things. It makes it hard for doctors to tell which virus is causing a person’s sickness — kinda like trying to figure out if you have a cold or the flu, but with more serious consequences.

The Need for Monitoring and Early Detection

Given these alarming trends, there’s an urgent need for ongoing monitoring and early detection of CHIKV. Keeping an eye on mosquito populations and tracking cases can help prevent larger outbreaks. Public health officials are keen on a multi-faceted approach that combines mosquito Surveillance and accurate disease diagnosis.

Field Work and Mosquito Traps

In the city of São José do Rio Preto, health officials initiated a mosquito surveillance program. They set up traps to catch mosquitoes and track their populations. The idea is simple: catch the mosquitoes, test them for CHIKV, and know what’s happening in the mosquito population. Scientists collected samples from various neighborhoods and conducted monthly checks to see how the mosquito situation was evolving.

The fieldworkers had to be sneaky, though. They needed to get permission from residents to set up their traps, which seemed like a fun game of “knock, knock” at each house. Once they got the green light, the traps were set up in shady spots close to trash piles or overgrown vacant lots — because where there’s junk, there are typically mosquitoes.

Getting Down to the Science

Once the mosquitoes were collected, they underwent a series of scientific tests to identify if CHIKV was present. This involved smashing the mosquitoes into a mix to extract viral RNA and using fancy techniques like real-time polymerase chain reaction (RT-qPCR) to check for the virus. It’s like finding a needle in a haystack, but instead, the needle is a virus, and the haystack is a bunch of mosquitoes.

The Numbers Tell the Story

From October 2023 to July 2024, scientists found a total of 1,183 mosquitoes in their traps. The majority, 62.9%, were Aedes aegypti, with Culex mosquitoes making up the rest. Out of these, 79 tested positive for CHIKV, which is a positivity rate of about 6.67%. That’s not great news when you're trying to keep a virus like this in check.

Seasonal Patterns

Interestingly, the collected data showed that Aedes mosquitoes were more common during certain months, which aligned with the rainy season. More rain means more standing water where mosquitoes can breed, leading to their population explosion.

Human Cases and the Connection to Mosquitoes

The ongoing monitoring of mosquitoes helped to connect the dots between mosquito populations and human CHIKV cases. As the mosquito positivity rate climbed, so did the number of reported human cases of chikungunya. It’s a classic case of “what goes around comes around.” More infected mosquitoes typically mean more sick people.

The Seriousness of Chikungunya Fever

CHIKV poses significant risks, particularly for those who become severely ill. While most people will recover, some may experience debilitating joint pain that lasts for months or even years—talk about a party crasher.

Long-Term Impact

This long-lasting pain can severely affect the quality of life for those infected. The symptoms can be so debilitating that some may find it difficult to go about their daily activities, making chikungunya not just a temporary nuisance but a long-term health issue.

Genetic Investigations

Scientists also delved into the genetics of the virus to understand its spread better. By extracting the complete genome of CHIKV from mosquitoes and humans, researchers could trace back its origins and how it has mutated over time. They found that the virus was frequently exchanged among regions, suggesting that it can travel faster than a rumor in a small town.

Phylogenetic Analysis

Using sophisticated tools, scientists mapped out how different strains of CHIKV are related to each other. They discovered that CHIKV strains from São Paulo had links to those in neighboring regions, which means that mosquitoes are not just sitting still; they are on the move, taking the virus with them.

Conclusion: A Call for Action

The rise of chikungunya in Brazil is a serious matter that requires immediate attention. Policymakers, health officials, and the public must all work together to address the mosquito populations and reduce the risk of further outbreaks.

Staying Ahead of the Curve

By implementing effective monitoring systems, public health measures, and community engagement, the spread of CHIKV can be curtailed. Continued research to understand the virus better will also play a critical role in mitigating its impact on society.

So, while chikungunya might stick around, it doesn’t have to wreak havoc. With the right actions and a little bit of teamwork, we can keep it in its place, allowing folks to go about their lives without fear of catching a nasty virus from a pesky mosquito.

Original Source

Title: Entomological surveillance during a major CHIKV outbreak in northwestern Sao Paulo: insights from Sao Jose do Rio Preto

Abstract: BackgroundBrazil is considered an epicenter for emerging and re-emerging arboviruses that significantly impact public health. The mid-sized city of Sao Jose do Rio Preto (SJdRP) in northwestern Sao Paulo state is considered hyperendemic for arboviral diseases, with case numbers climbing each year. Only 45 cases of chikungunya (CHIKV) were reported in the city from 2015 to 2022, indicating cryptic circulation of this virus, but cases in the state increased notably in 2023. This study investigates the use of active entomological surveillance to detect new arbovirus introductions in specific areas like SJdRP. Methodology/Principal findingsWe used molecular testing to investigate the presence of CHIKV in adult culicids collected monthly from various neighborhoods in SJdRP. Positive samples underwent whole-genome sequencing and phylogenetic analysis. Entomological surveillance successfully detected the early spread of CHIKV across SJdRP, revealing an infection rate of 6.67%, with the well-established vectors Aedes aegypti and Ae. albopictus as well as Culex sp. carrying the virus. The vector positivity rate increased from December 2023 to April 2024, which correlates with rising numbers of chikungunya fever cases reported in SJdRP during the same period. The resurgence of CHIKV in this region is attributed to several introduction events, mainly from the Southeast and North of Brazil, which facilitated establishment of the virus within the highly dense vector population and led to extensive spread and, in turn, a major CHIKV epidemic in this geographical area. Conclusions/significanceExtensive circulation of CHIKV was documented within the human and vector population, marking the onset of the first major CHIKV epidemic in SJdRP and neighboring cities. Because multiple arboviruses co-circulate in several locations in Brazil, entomological surveillance, along with ongoing monitoring of patient samples, is a key to help health authorities to implement more effective measures to interrupt transmission cycles and mitigate new epidemic waves. Author summaryThe city of Sao Jose do Rio Preto (SJdRP) in northwestern Sao Paulo state is an endemic area for dengue virus (DENV), but cases of chikungunya virus (CHIKV) were also reported between January and September 2023. Since overlapping symptoms between these acute febrile diseases can complicate differential diagnosis, the increase in CHIKV cases in DENV-endemic regions is concerning. Entomological surveillance is a useful strategy for accurate and early detection of arboviruses, making it possible to identify emerging or increased arbovirus activity, predict potential outbreaks, and support effective control measures, thus reducing impacts on public health. Through entomological surveillance we were able to detect the spread of CHIKV in SJdRP, revealing a high infection rate in the vector population. Our findings also suggest that the virus spread widely throughout the local mosquito population, potentially via vertical or sexual transmission, which may have contributed to sustained transmission during unfavorable conditions or inter-epidemic periods. We also observed a monthly increase in the vector populations positivity rate which correlates with a rise in CHIKV cases in the city and the first CHIKV outbreak in this area.

Authors: Cecília Artico Banho, Maisa Carla Pereira Parra, Olivia Borghi Nascimento, Gabriel Pires Magnani, Maria Vitoria Moraes Ferreira, Ana Paula Lemos, Beatriz de Carvalho Marques, Marini Lino Brancini, Livia Sacchetto, Andreia Francesli Negri, Regiane Maria Tironi Menezes, Juliana Telles de Deus, Cassia Fernanda Estofolete, Nikos Vasilakis, Maurício Lacerda Nogueira

Last Update: 2024-12-06 00:00:00

Language: English

Source URL: https://www.medrxiv.org/content/10.1101/2024.12.04.24318429

Source PDF: https://www.medrxiv.org/content/10.1101/2024.12.04.24318429.full.pdf

Licence: https://creativecommons.org/licenses/by/4.0/

Changes: This summary was created with assistance from AI and may have inaccuracies. For accurate information, please refer to the original source documents linked here.

Thank you to medrxiv for use of its open access interoperability.

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