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Confronting Antimicrobial Resistance in the Musi River

Exploring the impact of urbanization on AMR in Hyderabad's Musi River.

Vikas Sonkar, Arun Kashyap, Rebeca Pallarés-Vega, Sai Sugitha Sasidharan, Ankit Modi, Cansu Uluseker, Sangeetha Chandrakalabai Jambu, Pranab Kumar Mohapatra, Joshua Larsen, David Graham, Shashidhar Thatikonda, Jan-Ulrich Kreft

― 6 min read


AMR Crisis in Musi River AMR Crisis in Musi River resistance in Hyderabad's water. Urbanization fuels antimicrobial
Table of Contents

Antimicrobial Resistance (AMR) is when germs like bacteria stop responding to medicines that usually kill them or slow their growth. This makes treating infections much harder and creates a big health problem for people, animals, and even plants everywhere. Estimates say millions of people could die from infections caused by these resistant germs in the coming years.

Why is AMR a Big Deal?

AMR isn't a new issue; it's been around for ages. However, human actions, such as overusing antibiotics and poor waste management, have made it worse. We’re talking about practices like using too many antibiotics in farming, which people and animals consume. This creates a cycle where germs adapt and become resistant to treatments.

Focus on the Musi River

The Musi River, flowing through Hyderabad in India, paints a vivid picture of how Urbanization and AMR clash. The river is not just a water body; it has a vital role for the people living nearby. Sadly, rapid growth in Hyderabad means that many untreated wastes, including municipal and industrial, end up in the river. This could be a recipe for disaster.

The Health Risks in Hyderabad

In Hyderabad, nearly 60% of the municipal wastewater isn't treated before being dumped into the river. This means all sorts of nasty stuff, including resistant bacteria, find their way into the water. Since the river serves many purposes – from drinking water to irrigation – this poses a big health risk. The last thing anyone wants is to wash their vegetables with water contaminated with resistant germs.

The Role of Wastewater Treatment Plants

Wastewater Treatment Plants (WWTPs) are supposed to save the day by filtering out harmful substances from wastewater before it hits the river. However, the capacity of these plants in Hyderabad isn’t enough to cope with the large volumes of waste produced. So, while some treatment does happen, lots of waste still flows untreated.

Urbanization and AMR Transmission

As Hyderabad grows, so does the population. More people means more waste. Increased urbanization means that the chances of AMR spreading through the environment also rise. Think of it this way: more people produce more waste, and if proper systems aren't in place, bacteria hitch a ride on polluted water.

The Urgent Need to Understand AMR in the Musi River

Monitoring the levels of resistant bacteria and the genes that help them resist treatment in the Musi River is crucial. If we know what’s happening, we can take action to mitigate the spread of AMR. That means we need to keep tabs on bacteria, their genes, and how they change over time in the river's different sections.

Researching Along the Musi

Researchers set out to collect water and sediment samples from various points along the Musi River during both dry and wet seasons. The goal was to see how the levels of resistant bacteria and their genes fluctuate with the changing seasons. By doing this, scientists can better understand how waste affects bacterial populations in the river.

Why Seasons Matter?

The river experiences dry and wet seasons, which can affect the concentration of bacteria and genes. For instance, a heavy rain might wash more pollutants into the water, while dry periods could mean lower water levels and higher concentrations of whatever is in it already.

Sampling the Musi River

Sampling was done across ten locations along the river. This included both water and sediment samples. These samples give insights into what’s lurking in the water and on the riverbed. The more data collected, the clearer the picture of AMR in the river becomes.

The Battle of the Bacteria

Researchers are interested in bacteria like E. coli and other resistant strains. They analyze how many of these bacteria are present in both the water and sediment samples. By comparing these numbers across different seasons, scientists can see how pollution changes the dynamics among bacteria.

Understanding Water Quality

Good water quality is essential not just for drinking but for the overall health of the ecosystem. When researchers look at water quality, they check for things like oxygen levels, nitrogen content, and temperature. These factors can offer clues about what might be brewing in the water.

The Connection Between Water Quality and AMR

Water quality is deeply intertwined with AMR. For example, lower levels of oxygen and higher nitrogen levels often indicate poor water quality, which is frequently linked to higher levels of resistant bacteria. Understanding this relationship can help in tackling AMR effectively.

Statistical Magic: What’s the Data Telling Us?

Analyzing the collected data helps researchers spot patterns. They use statistical methods to see how water quality correlates with the presence of resistant bacteria. This can inform future actions and policies aimed at reducing AMR in water bodies.

Where Do the Bad Bacteria Come From?

Identifying where resistant bacteria come from can guide remediation efforts. With urban centers like Hyderabad, the most significant source is untreated wastewater. By understanding the contributions of different sources, researchers can prioritize actions to tackle the problem.

Seasonal Variations and Their Implications

Found patterns showed that resistant bacteria levels varied between seasons. Generally, bacteria levels rose during the wet season when rainwater could wash more contaminants into the river. Identifying why this happens can help optimize management strategies.

Looking at the Bigger Picture: AMR in Other Rivers

The situation in the Musi River is not unique. Many rivers in India and beyond face similar challenges, especially in areas with poor wastewater management and high population density. Understanding AMR in the Musi can lead to insights applicable to other rivers, helping create a framework for action worldwide.

Future Directions

There’s still much more to explore regarding AMR in rivers. Continued research will help refine models and identify effective solutions. Empowering communities to monitor their local water quality can also be an essential step in fighting this growing threat.

Conclusion: Taming the AMR Beast

The challenge of AMR is pressing, especially in heavily populated areas like Hyderabad. By understanding the dynamics of AMR in the Musi River, we can take guided steps towards reducing the spread of resistant bacteria. With effective water quality management, regional cooperation, and community engagement, there’s hope for tackling this issue head-on.

Taking Action Against AMR

While the road ahead may seem daunting, awareness and action can bridge the gap. Minimizing wastewater contamination, improving treatment facilities, and adopting better agricultural practices can have a significant impact. As individuals, monitoring our waterways and demanding action can also play a vital role in protecting our health and environment.

A Call for Change

In the end, tackling AMR is not just about improving human health; it’s about securing a healthier planet for all living beings. It’s about leaving a legacy of clean water and healthy ecosystems for future generations.

Let’s Make Waves!

By working together towards smarter practices and increased awareness, we can turn the tide against antimicrobial resistance and ensure our rivers remain vibrant and safe for all. The journey may be long, but every little change counts in the grand scheme of protecting our health and our water resources.

Original Source

Title: Field monitoring and hydraulic modelling quantify untreated wastewater as dominant source of AMR in a small river running through a big city

Abstract: Antimicrobial resistance (AMR) is a silent pandemic, which is transmitted and spread through the environment. Few of many studies on waterborne AMR spread have characterised the prevalence, sources, and transport of AMR in adequate detail to inform mathematical modelling and exposure risk assessments. Here, we quantified taxonomic and resistance genes (ARGs), sensitive and resistant bacteria (ARBs), and environmental conditions in water and sediment samples at ten locations along the Musi River through Hyderabad, a city renowned for antimicrobial manufacturing, to develop a hydraulic model for AMR spread in the catchment. In the dry season, absolute water column ARG and ARB abundances increased rapidly upon entering the city, then declined downstream. In the wet season, the increase and decline of AMR levels was more gradual. Clustering and ordination of ARGs separated the river into three stretches: upstream, city, and downstream. Most ARGs and water quality indicators differed significantly between stretches and seasons (p View larger version (21K): [email protected]@[email protected]@16f14db_HPS_FORMAT_FIGEXP M_FIG C_FIG HighlightsO_LIWithin the city, the concentration of ARGs and ARBs increases in the dry season C_LIO_LIClustering and ordination of ARGs separates upstream, city and downstream stretches C_LIO_LIPERMANOVA shows stretches and seasons are significantly different C_LIO_LILDA can discriminate stretches and seasons based on water quality parameters C_LIO_LIPoint source load calculations indicate 60-80% of river water is untreated wastewater C_LI

Authors: Vikas Sonkar, Arun Kashyap, Rebeca Pallarés-Vega, Sai Sugitha Sasidharan, Ankit Modi, Cansu Uluseker, Sangeetha Chandrakalabai Jambu, Pranab Kumar Mohapatra, Joshua Larsen, David Graham, Shashidhar Thatikonda, Jan-Ulrich Kreft

Last Update: 2024-12-21 00:00:00

Language: English

Source URL: https://www.biorxiv.org/content/10.1101/2024.12.21.629897

Source PDF: https://www.biorxiv.org/content/10.1101/2024.12.21.629897.full.pdf

Licence: https://creativecommons.org/licenses/by-nc/4.0/

Changes: This summary was created with assistance from AI and may have inaccuracies. For accurate information, please refer to the original source documents linked here.

Thank you to biorxiv for use of its open access interoperability.

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