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How Our Brains Control Memories

Discover how memory control helps manage unwanted thoughts.

Davide F. Stramaccia, Frederik Bergmann, Katharina Lingelbach, Ole Numssen, Gesa Hartwigsen, Roland G. Benoit

― 6 min read


Mastering Memory Control Mastering Memory Control memories. Learn how our brain suppresses unwanted
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Memory is a funny thing. One moment, you’re laughing with friends about a past adventure, and the next, an unwanted memory pops into your head like an unexpected guest at a party. This can be annoying, especially when that guest is wearing a terrible outfit and is eager to share embarrassing stories. To cope with this, our brains have a tricky mechanism called memory control, which helps us manage what memories we focus on.

What is Memory Control?

Memory control allows us to suppress unwanted memories, preventing them from popping up at inconvenient times. Think of this as a mental "do not disturb" sign. When we encounter reminders of a memory we’d rather forget, our brain tries to stop that memory from coming into our mind. This is important for maintaining emotional well-being and getting on with everyday life.

The Mechanism Behind Memory Control

One of the mechanisms responsible for this suppression is called retrieval suppression. This fancy term refers to how our brain actively inhibits the retrieval of memories that we want to avoid. In simpler terms, it's like telling your brain, "Nope, I do not want to think about that right now!" This process can weaken the memory over time, making it less likely to intrude into our thoughts later on.

Neuroscientists believe that certain brain regions play a crucial role in this process. Particularly, the Right Dorsolateral Prefrontal Cortex (dlPFC) has been highlighted as a key player in memory suppression. It acts as a gatekeeper, helping to enforce our mental "do not disturb" sign.

The Brain’s Party Planner: The Right Dorsolateral Prefrontal Cortex

Think of the right dlPFC as the bouncer at a club, determining who gets in and who stays out. When an unwanted memory tries to invade our thoughts, the dlPFC kicks it out, allowing only the memories we want to keep.

Several studies have shown that when we successfully suppress a memory, the dlPFC is more active, while a region called the Hippocampus-responsible for forming memories-showed reduced activity. This suggests that the dlPFC is sending the hippocampus a message to quiet down, much like a parent telling their kids to keep it down during a movie.

Evidence from Brain Imaging

Researchers have used brain imaging techniques to peek inside people’s heads and see what's going on during memory suppression. These studies consistently show that when participants try to suppress memories, the right dlPFC lights up like a Christmas tree, while the hippocampus dims its lights. It’s almost like the dlPFC is turning the volume down on the hippocampus, making it harder for those pesky memories to be retrieved.

A New Twist: Testing the Right dlPFC

To dig deeper into how the right dlPFC works, researchers conducted an experiment using a technique called transcranial magnetic stimulation (TMS). This method allows scientists to temporarily disrupt brain activity in specific areas. It’s like giving the bouncer a day off and seeing what happens at the club.

In this study, participants learned pairs of words, and later, they were asked to recall or suppress memories associated with these words. Some brain cells got a little zapped in the right dlPFC to see if that made it harder for participants to control their memories.

The Experiment's Design

Participants first learned pairs of cue and target words. Later, during the suppression phase, they were presented with some cues in green and asked to remember the associated words (think items), and others in red, where they tried not to recall the associated words (no-think items). Think of it as a game of "Simon Says," where sometimes you have to remember and sometimes you have to forget.

To see how well participants could suppress memories, researchers used two types of stimulation: one on the right dlPFC and one on the primary motor cortex (M1) as a control site. This allowed them to see if disrupting the dlPFC made it harder to suppress memories compared to when the M1 was stimulated.

Analyzing the Results

Once the tasks were completed, researchers assessed how well participants recalled the memories. They compared performance between the no-think items, the think items, and a baseline condition where no cues were provided. This way, they could understand whether memory suppression had any lasting effects.

Participants were also asked how often thoughts intruded into their awareness during the no-think trials. This added another layer to understanding how well they could suppress memories.

The Findings

The results were quite revealing. Participants reported that they had a harder time preventing unwanted memories from coming to mind when their right dlPFC was disrupted. It was as if the bouncer had forgotten his job and let all the unwanted guests into the party!

Interestingly, the researchers found that suppression-induced forgetting-which is when memories weaken as a result of active suppression-only occurred when the M1 was stimulated, not when the dlPFC was zapped. This suggests that while the right dlPFC helps to prevent retrieval in the short term, it may not have the same effect on the long-term weakening of those memories.

What’s the Takeaway?

This study supports the idea that the right dlPFC plays a significant role in controlling our memories. When it’s functioning well, it helps us keep unwanted memories at bay. But when it’s not, well, those pesky memories can crash the party.

Implications for Everyday Life

So, what does all of this mean for us? Understanding how our brains manage memories can help us find better strategies for dealing with unwanted thoughts. Whether it’s anxiety, trauma, or just those embarrassing moments we’d like to forget, knowing that we can suppress memories with the right mental tools is empowering.

Future Directions

This research opens the door for further investigations into memory control. Future studies can look at how different tasks and contexts affect the ability to suppress memories. Plus, there’s always the opportunity to develop new approaches for helping people manage intrusive thoughts, which could be particularly helpful for those dealing with traumatic experiences.

In Conclusion

Memory control is a fascinating topic that highlights how our brains work to manage the flood of information we encounter daily. The role of the right dlPFC in suppressing unwanted memories allows us to maintain our mental well-being and focus on the present.

Next time you find yourself struggling to keep a memory at bay, just remember: your brain has a built-in strategy to help you out. And if all else fails, just change the subject-because who really wants to be stuck reminiscing about that embarrassing moment, anyway?

Original Source

Title: Hindering memory suppression by perturbing the right dorsolateral prefrontal cortex

Abstract: A reminder of the past can trigger the involuntary retrieval of an unwanted memory. Yet, we can intentionally stop this process and thus prevent the memory from entering awareness. Such suppression not only transiently hinders the retrieval of the memory, it can also induce forgetting. Neuroimaging has implicated the right dorsolateral prefrontal cortex (dlPFC) in initiating this process. Specifically, this region seems to downregulate activity in brain systems that would otherwise support the reinstatement of the memory. We here probed the causal contribution of the right dlPFC to suppression by combining the Think/No-Think task with repetitive transcranial magnetic stimulation (rTMS). Participants first learned pairs of cue and target words, and then repeatedly recalled some of the targets (think condition) and suppressed others (no-think condition). We applied 10 Hz rTMS bursts to the right dlPFC during the suppression of half the no-think items, and to the contralateral primary motor area (M1) as an active control site during the other half. As hypothesized, participants experienced less success at keeping the memories out of awareness with concurrent dlPFC than M1 stimulation. Similarly, a memory test yielded evidence for suppression-induced forgetting (SIF) following M1 but not dlPFC stimulation. However, the difference in forgetting between the stimulation conditions was not significant. The study thus provides causal evidence for the role of the dlPFC in preventing retrieval. Future work will need to conclusively establish the relationship between this transient effect and suppression-induced forgetting.

Authors: Davide F. Stramaccia, Frederik Bergmann, Katharina Lingelbach, Ole Numssen, Gesa Hartwigsen, Roland G. Benoit

Last Update: Dec 26, 2024

Language: English

Source URL: https://www.biorxiv.org/content/10.1101/2024.12.23.630167

Source PDF: https://www.biorxiv.org/content/10.1101/2024.12.23.630167.full.pdf

Licence: https://creativecommons.org/licenses/by-nc/4.0/

Changes: This summary was created with assistance from AI and may have inaccuracies. For accurate information, please refer to the original source documents linked here.

Thank you to biorxiv for use of its open access interoperability.

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