Dengue: A Rising Global Health Threat
Dengue cases are increasing, with women facing greater risks and complications.
Ananda Wijewickrama, Heshan Kuruppu, Damayanthi Idampitiya, Rivindu Wickramanayake, Anagi Kottahachchi, Jeewantha Jayamali, Padukkage Harshani Chathurangika, Nushara Senatilleke, Navanjana Warnakulasuriya, Chandima Jeewandara, Gathsaurie Neelika Malavige
― 5 min read
Table of Contents
Dengue is a mosquito-borne viral infection that can lead to Severe illness. It has become a serious health threat around the world. The World Health Organization (WHO) has identified dengue as one of the top health risks, especially with rising numbers of cases in recent years. Many people experience mild symptoms, but for some, it can lead to severe complications and even death.
Increasing Cases and Severity
Since 2019, dengue cases have surged globally, with over 10 million reported cases in just the first half of 2024. This is alarming. The illness seems to be hitting adults more than younger people, which is a shift from past trends. This is concerning because older individuals and those with existing health issues are more likely to suffer from severe dengue. If you throw pregnancy into the mix, you have quite a few vulnerable people at risk.
Dengue can sometimes lead to serious outcomes like shock, organ failure, or severe Bleeding. While the majority of those infected have mild symptoms, some may experience complications such as fluid accumulation in the lungs or abdomen. Risk factors for severe cases include older age, existing health conditions like diabetes, and being pregnant. It is also noteworthy that studies show women, especially those of childbearing age, may have a higher risk of severe dengue and a higher chance of dying from the illness compared to men.
Gender Differences in Cases
Interestingly, even when the number of infected males is higher, females often experience worse outcomes. For example, in Bangladesh, more women died from dengue despite more male patients being hospitalized. This trend has also been seen in Brazil and Sri Lanka, where women face a higher risk of severe illness and death.
Now, you might wonder why this is the case. The reasons aren't entirely clear. It could be that women seek medical help later than men due to social roles, or perhaps they suffer from more complications when infected.
One complication that has been noted is per vaginal bleeding, which can occur in women during a dengue infection. Although this kind of bleeding is usually not a big deal for healthy individuals, it can worsen the situation for those already suffering from fluid loss due to the disease.
Study on Female Patients with Dengue
To better understand how dengue affects women, especially regarding per vaginal bleeding, researchers studied a large group of female patients with dengue in Sri Lanka. They looked at 288 women aged 18 and older who were admitted for dengue treatment. The researchers checked for signs of fluid leakage and recorded various symptoms and lab results during their hospital stay.
Among these women, about 10% reported experiencing bleeding, which is not something you want to hear during a dengue infection. Those with per vaginal bleeding were more likely to have severe forms of the disease compared to those who didn’t bleed.
The study found that women with bleeding reported additional warning signs such as abdominal pain, vomiting, and even diarrhea, which is not your usual symptom list for a viral infection. These women also had a higher likelihood of experiencing significant changes in blood counts.
Treatment Approaches
When women developed per vaginal bleeding, they received standard care, which included medications to reduce bleeding and manage symptoms. The hospital provided Treatments like intravenous fluids and sometimes blood transfusions, depending on the severity of the cases.
Though there was no striking difference in overall outcomes, the treatment given seemed to benefit women who bled. The proactive measures, such as quick administration of medications, may have helped prevent serious complications related to bleeding.
Why Is It Important to Know?
Understanding the frequency and impact of per vaginal bleeding during dengue is vital because it helps in the management of patients. The occurrence of this symptom is not well-documented in existing literature, which means more research is needed in this area.
Women can experience bleeding during their menstrual cycles, so this adds another layer of complexity when diagnosing and treating dengue. Knowing how often this happens and what it means could improve care for female patients.
The Bigger Picture
Dengue is not just a health crisis; it’s a situation that keeps medical professionals on their toes. Cases are rising each year, and while Sri Lanka has managed to reduce death rates from dengue significantly, that doesn't mean the fight is over. In 2024, a small number of patients still succumbed to the illness, and a majority of them were women.
This raises questions about why women, particularly those of reproductive age, are more likely to die from dengue than men. Understanding the reasons behind these gender differences can lead to better prevention and treatment strategies, potentially saving lives.
Final Thoughts
Dengue is a tricky virus that can leave you feeling quite miserable, and it’s especially challenging for women who face unique risks. The increase in cases globally calls for continued public health efforts to educate people about the disease, improve access to care, and ensure that patients receive timely treatment.
While the issue at hand might seem serious, we can take comfort in knowing that medical professionals are working hard to study these patterns and improve patient outcomes. So, next time you hear about dengue, remember it’s not just about the number of cases. It’s also about the stories, experiences, and lives affected by this pesky virus.
Stay Informed and Safe
As dengue continues to be a public health issue, staying informed about its symptoms and treatment options is important. If you find yourself or someone you know experiencing symptoms, getting medical help early can make a significant difference. So, don’t hesitate—seek help, and keep those pesky mosquitoes at bay!
Original Source
Title: Per vaginal bleeding-an important but ignored feature of dengue
Abstract: BackgroundElderly individuals, those with comorbidities and pregnant women are at a higher risk of developing severe dengue and succumbing to their illness. However, an increased incidence of severe dengue and fatalities are seen in females of the reproductive age. As per vaginal (PV) bleeding is an important complication that has not been well characterized, we sought to determine the frequency, complications and disease outcomes in women who develop PV bleeding. Methodology/Principal findings288 adult female patients were recruited from the National Institute of Infectious Diseases Sri Lanka. All clinical features and laboratory investigations were recorded throughout the duration of hospital admission along with treatment received. 28/288 (9.72%) reported PV bleeding, with 12/28 (42.85%) developing dengue haemorrhagic fever (DHF) compared to 65/260 (25%) of those who did not have bleeding. Women who developed PV bleeding were more likely to have developed DHF (OR 2.2, 95% CI 0.98 to 5.1, p=0.06), abdominal pain (OR=2.17, 95% CI = 0.99 to 4.69, p = 0.06), vomiting (OR= 2.0, 95% CI= 0.89 to 4.44, p= 0.10), diarhoea (OR= 4.35, 95% CI = 1.908 to 9.610, p= 0.0004) or evidence of any fluid leakage (OR= 1.98, 95% CI = 0.91 to 4.5, p = 0.11). Although not significant, those who had PV bleeding were more likely to have been given intravenous fluids, blood transfusions and colloids. ConclusionsPV bleeding appears to associate with worse disease outcomes. The possible contribution of PV bleeding to higher incidence of severe dengue and fatality rates observed in many countries, should be further investigated. Author summaryElderly individuals, those with comorbidities and pregnant women are at a higher risk of developing severe dengue and succumbing to their illness. However, an increased incidence of severe dengue and fatalities are seen in females of the reproductive age. As per vaginal (PV) bleeding is an important complication that has not been well characterized, we investigated the complications and disease outcomes in women who developed PV bleeding, by studying clinical and laboratory characteristics of 288 women with acute dengue. 28 (9.72%) reported PV bleeding, with 42.85% developing dengue haemorrhagic fever (DHF). Women who developed PV bleeding were more likely to have developed DHF, abdominal pain, vomiting, diarhoea or evidence of any fluid leakage. They were more likely to have been given intravenous fluids, blood transfusions and colloids. Therefore, the possible contribution of PV bleeding to higher incidence of severe dengue and fatality rates in many countries should be further investigated.
Authors: Ananda Wijewickrama, Heshan Kuruppu, Damayanthi Idampitiya, Rivindu Wickramanayake, Anagi Kottahachchi, Jeewantha Jayamali, Padukkage Harshani Chathurangika, Nushara Senatilleke, Navanjana Warnakulasuriya, Chandima Jeewandara, Gathsaurie Neelika Malavige
Last Update: 2024-12-26 00:00:00
Language: English
Source URL: https://www.medrxiv.org/content/10.1101/2024.12.23.24319534
Source PDF: https://www.medrxiv.org/content/10.1101/2024.12.23.24319534.full.pdf
Licence: https://creativecommons.org/licenses/by/4.0/
Changes: This summary was created with assistance from AI and may have inaccuracies. For accurate information, please refer to the original source documents linked here.
Thank you to medrxiv for use of its open access interoperability.