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Treating BPH: A Promising Alternative to Surgery

Rezūm® therapy offers hope for men dealing with enlarged prostate symptoms.

Dr. Mario González, Dra. Milena Castro

― 6 min read


BPH Treatment: Rezūm® BPH Treatment: Rezūm® Therapy Wins for enlarged prostate symptoms. Water vapor therapy proves effective
Table of Contents

Benign Prostatic Hyperplasia, commonly known as BPH, is a condition that affects many men, especially those in their 40s and 50s. Now, before you start thinking this sounds like some kind of complicated medical term, let’s break it down. BPH is simply an enlarged prostate, the gland that’s responsible for producing some of the fluid in semen. When this gland gets bigger, it can squeeze the urethra, which is the tube that carries urine out of the body. This leads to some pretty uncomfortable bathroom trips, known as lower urinary tract symptoms (LUTs).

Imagine having to rush to the bathroom every time you hear a running tap or having to wake up multiple times during the night just to relieve yourself. Not fun, right? For many men, these symptoms can seriously affect their quality of life.

Treating BPH

Traditionally, the go-to treatment for BPH has been surgery. While surgery can be effective, it is not without its drawbacks. Some procedures are invasive and can lead to various side effects that no one really wants to deal with. Enter the world of minimally invasive therapies, which aim to treat BPH while minimizing discomfort and recovery time.

One of these therapies is called Rezūm®. This procedure utilizes water vapor to reduce the size of the prostate. Yes, you heard that right—water vapor! It’s like boiling a kettle but for your prostate. Patients generally find it has beneficial results, which is why a study was conducted in Costa Rica to see how effective it could be for local men.

A Closer Look at the Costa Rican Study

The Costa Rican research wasn’t just a casual hangout over some coffee; it aimed to collect solid evidence about the effectiveness of Rezūm® on patients diagnosed with BPH. The study looked at various international studies, confirming that this research was needed in Costa Rica since there had been more studies in countries like the USA, France, and the UK.

In this study, researchers focused on analyzing the prostate size before and after the Rezūm® treatment. They also monitored LUTS using a measurement called the International Prostate Symptom Score (IPSS). This score helps to gauge how annoying those bathroom trips can be for men dealing with BPH.

What Happens During the Rezūm® Procedure?

So, what’s it like to get the Rezūm® treatment? First off, it’s done in an outpatient setting, which means you can go home the same day. Once you’re comfortably settled in, the healthcare team gives you some mild sedation—or as I like to call it, a "nap starter." After ensuring everything is safe and sound (like no underlying prostate cancer), the procedure begins.

A doctor then uses a thin tube called a catheter to deliver water vapor directly into the prostate. This vapor effectively shrinks the prostate over time. The entire process takes about 15 minutes, which is shorter than some reality show episodes.

After the treatment, patients usually have a catheter left in for about five days to help with urine flow while the body recovers. Post-procedure, follow-up visits are scheduled at 1, 3, and 6 months to keep tabs on how well the treatment is working.

Understanding the Study's Methods

The researchers didn’t just wing it and hope for the best; they had a well-laid plan. They reviewed clinical records from a hospital database to pull the necessary data. They focused on measuring prostate volume and assessing LUTS through the IPSS. Basically, they wanted to see how much prostate size changed and how much healthier the men felt post-treatment.

In total, they reviewed 343 cases of men who had undergone the procedure. Out of those, they narrowed it down to 342 after excluding one record due to missing info. They used various methods and measurements to ensure they would get a clear picture of how effective Rezūm® truly is.

What Did They Find?

The results were promising. The average age of the men in the study was about 64. Before treatment, the average prostate size was approximately 47 grams. Sounds like a lot, right? But after the Rezūm® procedure, the men experienced a reduction in prostate volume by an average of 21 grams. With an average of six water vapor applications, this means their prostates shrank significantly!

But that’s not all. Along with a smaller prostate, the follow-up visits revealed that the IPSS scores dropped dramatically, indicating fewer symptoms and a happier bathroom experience for these men.

Breaking Down the Numbers

Numbers can sometimes feel dry, but let's make it a little more interesting. Picture a group of gentlemen each battling their own urinary issues. After undergoing Rezūm®, they found they needed to rush to the bathroom less often. The average IPSS score at the beginning of the study was 17 points; post-treatment, it dropped to an average of just 3 points. Talk about a major upgrade!

When it comes to urinary flow rate, men saw improvements here too. Their average flow rate went from a sluggish 12 ml/sec to a much better 19 ml/sec after treatment. If only we could all experience such impressive upgrades!

The Variability Factor

Like any good study, there are some variations to note. The researchers found that men aged 60-69 showed the most variation in results, indicating that this age group might experience a range of outcomes from the treatment. It’s like a surprise party—some guests might love it, and others might be indifferent.

The researchers also took a closer look at why some men dropped out of the follow-up. Many of these men didn't return for various reasons, including moving out of the country or health complications.

Interpreting the Findings

The reductions in prostate size and symptomatic relief suggest a clear benefit from the Rezūm® treatment. These findings support the idea that less invasive procedures can indeed offer significant relief to men suffering from BPH without going under the knife.

So, what does all this mean for our everyday superheroes? It means that for many men battling an enlarged prostate, there are effective alternatives out there that can improve their quality of life.

What’s Next?

As with any medical treatment, there are always areas for improvement and further understanding. Future studies could look at additional factors, like how these treatments might influence other aspects of male health, such as erectile function.

By broadening the scope of research and understanding the interplay of various health conditions, we can get a better handle on how to combat BPH and similar issues effectively.

Conclusion

In summary, BPH is a common issue for many men as they age. Fortunately, effective treatments like Rezūm® are providing significant relief without the need for invasive surgery. With an average prostate volume decrease of 21 grams and notable reductions in urinary symptoms, patients can breathe a sigh of relief—or at least a less rushed one!

As the saying goes, "Not all heroes wear capes." In this case, some wear hospital gowns and come out feeling like a million bucks, all thanks to a bit of water vapor therapy!

Original Source

Title: Efficacy of Rezum(R) in reducing prostate volume. A retrospective study in patients with benign hyperplasia in Costa Rica.

Abstract: AimTo estimate the effect size of the prostate volume reduction after application of water vapor injections (Rez[u]m(R)) in 40 years or older patients, that have been diagnosed with Benign Prostate Hyperplasia (BPH) and are registered at UNIBE Hospital. This contrast provides a retrospective efficacy of the minimally invasive treatment valid for the local population. MethodsA retrospective study was conducted to review patient records, attended at UNIBE Hospital, in Costa Rica. Prostate volume was established as the main variable to assess BPH reversion. Other variables like the International Prostate Symptome Score (IPSS) and urinary flow rate were also evaluated for each patient. Two sample mean comparisons of baseline and follow up measures for prostate volume and IPSS were calculated to estimate a mean difference. Effect size parameters like Cohens d, Hedgess g and Glasss{delta} were also estimated and compared based on the standard deviation assessment. A linear regression model was also adjusted to obtain values of the statistical contribution from each of the variables included to evaluate the clinical reversal of a benign prostate hyperplasia diagnosis. ResultsAfter data extraction from clinical records, 289 patients had complete data for this assessment, resulting in a 15% of missing values from the initial sample of records reviewed. The baseline prostate volume mean was 47 grams with a standard deviation of 14 grams, and the follow up mean was estimated at 26 grams with a standard deviation of 9 grams. After statistical comparison, this reduction was statistically significant for the observed evidence. A difference between the sample means can be expected to be as extreme as 21 grams with a p-value < 0.0001% of the times under the null hypothesis. Therefore, there is sufficient evidence to reject the null hypothesis. An IPSS of 17,47 score units (6,46 score units of standard deviation) was obtained before treatment for the 289 patient records reviewed, whereas reported IPSS after treatment was estimated with an average of 2score units with a standard deviation of 2 score units. Mean difference contrast for IPSS showed a statistically significant difference with a p-value less than 0,0001, and estimating an average difference of 14,72 score units. A change on the symptom manifestation after treatment is related with a clinical quality of life indicator. Urinary flow rate increased to an average of 19 ml/sec and a standard deviation of 5 ml/sec after procedure was applied. A linear regression model was adjusted using number of applications, age, prostate volume at baseline, IPSS at baseline and urinary flow rate at baseline; obtaining an variability explanation rate of 57% from these variables. ConclusionThere is enough evidence to expect an effective reduction on the prostate volume when applying Rez[u]m(R) water vapor therapy in Costa Rican men. IPSS also showed significant evidence to support the efficacy impact on the reduction of symptoms (mean difference was 14,72 average score units). An effect size of 21 grams of difference after applications was obtained with 1.7 standard deviations lower than the baseline measure. InterpretationA difference in prostate volume of 20.97 average grams was obtained and quality of life was increased significantly, after REZUM treatment was applied.

Authors: Dr. Mario González, Dra. Milena Castro

Last Update: 2024-12-26 00:00:00

Language: English

Source URL: https://www.medrxiv.org/content/10.1101/2024.12.22.24319507

Source PDF: https://www.medrxiv.org/content/10.1101/2024.12.22.24319507.full.pdf

Licence: https://creativecommons.org/licenses/by/4.0/

Changes: This summary was created with assistance from AI and may have inaccuracies. For accurate information, please refer to the original source documents linked here.

Thank you to medrxiv for use of its open access interoperability.

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